High-Impact Research Publications Using ADInstruments

Descending motor drive does not interact with muscle metaboreflex for ventilation regulation during rhythmic exercise in healthy humans

Voluntary (i.e., with descending motor drive) and involuntary (i.e., no descending motor drive) plantar flexion elicited similar ventilatory responses when postexercise circulatory occlusion was or was not used in an upper limb. These results indicate that the…

DOI: 10.1152/ajplung.00183.2024

A Genomic Link From Heart Failure to Atrial Fibrillation Risk: FOG2 Modulates a TBX5/GATA4-Dependent Atrial Gene Regulatory Network

BACKGROUND: The relationship between heart failure (HF) and atrial fibrillation (AF) is clear, with up to half of patients with HF progressing to AF. The pathophysiological basis of AF in the context of HF is presumed to result from…

DOI: 10.1161/circulationaha.123.066804

A less-invasive left atrial assist device concept for diastolic heart failure: First in vitro and in vivo assessment

DOI: 10.1016/j.xjon.2024.08.011

A three-dimensional liquid diode for soft, integrated permeable electronics

DOI: 10.1038/s41586-024-07161-1

All-optical reporting of inhibitory receptor driving force in the nervous system

Abstract Ionic driving forces provide the net electromotive force for ion movement across receptors, channels, and transporters, and are a fundamental property of all cells. In the nervous system, fast synaptic inhibitio…

DOI: 10.1038/s41467-024-53074-y

Analysis of ventricular repolarization parameters and heart rate variability in obesity: a comparative study

Abstract Obesity is associated with dysfunctional electrocardiographic and cardiac autonomic parameters, which may lead to increased cardiovascular morbidity. Novel electrocardiographic repolarization markers such as Tpeak-Tend (Tpe) interval have n…

DOI: 10.1038/s41598-024-76580-x

Anti-lymphangiogenesis for boosting drug accumulation in tumors

Abstract The inadequate tumor accumulation of anti-cancer agents is a major shortcoming of current therapeutic drugs and remains an even more significant concern in the clinical prospects for nanomedicines. Various strategies aiming at regulating the intratum…

DOI: 10.1038/s41392-024-01794-4

AS160 is a lipid-responsive regulator of cardiac Ca2+ homeostasis by controlling lysophosphatidylinositol metabolism and signaling

DOI: 10.1038/s41467-024-54031-5

Autologous cell transplantation for treatment of colorectal aganglionosis in mice

Abstract Neurointestinal diseases cause significant morbidity and effective treatments are lacking. This study aimes to test the feasibility of transplanting autologous enteric neural stem cells (ENSCs) to rescue the ent…

DOI: 10.1038/s41467-024-46793-9

Battery-free, wireless, and electricity-driven soft swimmer for water quality and virus monitoring

Miniaturized mobile electronic system is an effective candidate for in situ exploration of confined spaces. However, realizing such system still faces challenges in powering issue, untethered mobility, wireless data acquisition, sensing versatility, and integr…

DOI: 10.1126/sciadv.adk6301