High-Impact Research Publications Using ADInstruments

Ultra-low extracorporeal volume microfluidic leukapheresis is safe and effective in a rat model

Abstract Leukapheresis is a potentially life-saving therapy for children with symptomatic hyperleukocytosis. However, the standard centrifugation-based approach exposes pediatric patients to significant complications due to its large extracorporeal…

DOI: 10.1038/s41467-025-57003-5

Upregulated FoxO1 promotes arrhythmogenesis in mice with heart failure and preserved ejection fraction

DOI: 10.1038/s41467-025-56186-1

UW supplementation with AP39 improves liver viability following static cold storage

DOI: 10.1038/s41598-025-85302-w

VITALS: an implantable sensor network for postoperative cardiac monitoring in heart failure patients

DOI: 10.1038/s44385-025-00017-x

WAND: A multi-modal dataset integrating advanced MRI, MEG, and TMS for multi-scale brain analysis

Abstract This paper introduces the Welsh Advanced Neuroimaging Database (WAND), a multi-scale, multi-modal imaging dataset comprising in vivo brain data from 170 healthy volunteers…

DOI: 10.1038/s41597-024-04154-7

A minimally invasive thrombotic model to study stroke in awake mice

DOI: 10.1038/s41467-025-59617-1

Chronic circadian disruption alters cardiac function and glucose regulation in mice

DOI: 10.1038/s44323-025-00032-6

Control of spatiotemporal activation of organ-specific fibers in the swine vagus nerve by intermittent interferential current stimulation

DOI: 10.1038/s41467-025-59595-4

cSTAR analysis identifies endothelial cell cycle as a key regulator of flow-dependent artery remodeling

Fluid shear stress (FSS) from blood flow sensed by vascular endothelial cells (ECs) determines vessel behavior, but regulatory mechanisms are only partially understood. We used cell state transition assessment and regulation (cSTAR), a powerful computational m…

DOI: 10.1126/sciadv.ado9970

Deferiprone ameliorates cisplatin induced peripheral neurotoxicity via ferritinophagy adjustment

Abstract Cisplatin-induced neurotoxicity is one of the limiting factors to its use especially in tumors that demand high drug dosage. One of the Cisplatin pathways is ferritinophagy which may end up in ferroptosis. So, we aimed to use iron chelator…

DOI: 10.1038/s41598-025-87628-x