High-Impact Research Publications Using ADInstruments

Millimeter-scale magnetic implants paired with a fully integrated wearable device for wireless biophysical and biochemical sensing

Implantable sensors can directly interface with various organs for precise evaluation of health status. However, extracting signals from such sensors mainly requires transcutaneous wires, integrated circuit chips, or cumbersome readout equipment, which increas…

DOI: 10.1126/sciadv.adm9314

Mitophagy curtails cytosolic mtDNA-dependent activation of cGAS/STING inflammation during aging

Abstract Macroautophagy decreases with age, and this change is considered a hallmark of the aging process. It remains unknown whether mitophagy, the essential selective autophagic degradation of mitochondria, also decreases with age. In our…

DOI: 10.1038/s41467-024-45044-1

Modified C-type natriuretic peptide normalizes tumor vasculature, reinvigorates antitumor immunity, and improves solid tumor therapies

Deficit of oxygen and nutrients in the tumor microenvironment (TME) triggers abnormal angiogenesis that produces dysfunctional and leaky blood vessels, which fail to adequately perfuse tumor tissues. Resulting hypoxia, exacerbation of metabolic disturbances, a…

DOI: 10.1126/scitranslmed.adn0904

More efficient adaptation of cardiovascular response to repeated restraint in spontaneously hypertensive rats: the role of autonomic nervous system

Abstract We hypothesized that sympathetic hyperactivity and parasympathetic insuficiency in spontaneously hypertensive rats (SHR) underlie their exaggerated cardiovascular response to acute stress and impaired adaptation to repeated restrain…

DOI: 10.1038/s41440-024-01765-w

Multiple beta cell-independent mechanisms drive hypoglycemia in Timothy syndrome

DOI: 10.1038/s41467-024-52885-3

Mussel-inspired thermo-switchable underwater adhesive based on a Janus hydrogel

Abstract On-demand underwater adhesives with excellent adhesive and gentle detachment properties enable stable connections to various biomedical devices and biointerfaces and avoid the risk of harmful tissue damage upon detachment. Herein, w…

DOI: 10.1038/s41427-024-00569-1

Nadir blood pressure responses to longer consecutive cardiac cycle sequences absent of sympathetic bursts are associated with popliteal endothelial-dependent dilation

DOI: 10.1016/j.autneu.2024.103193

Naked mole-rats have distinctive cardiometabolic and genetic adaptations to their underground low-oxygen lifestyles

Abstract The naked mole-rat Heterocephalus glaber is a eusocial mammal exhibiting extreme longevity (37-year lifespan), extraordinary resistance to hypoxia and absence of cardiovas…

DOI: 10.1038/s41467-024-46470-x

Nanoporous graphene-based thin-film microelectrodes for in vivo high-resolution neural recording and stimulation

Abstract One of the critical factors determining the performance of neural interfaces is the electrode material used to establish electrical communication with the neural tissue, which needs to meet strict electrical, el…

DOI: 10.1038/s41565-023-01570-5

Despite plasticity, heatwaves are costly for a coral reef fish

Abstract Climate change is intensifying extreme weather events, including marine heatwaves, which are prolonged periods of anomalously high sea surface temperature that pose a novel threat to aquatic animals. Tropical animals may be especially vulnerable to m…

DOI: 10.1038/s41598-024-63273-8