High-Impact Research Publications Using ADInstruments

Gut microbiota-dependent increase in phenylacetic acid induces endothelial cell senescence during aging

Abstract Endothelial cell senescence is a key driver of cardiovascular aging, yet little is known about the mechanisms by which it is induced in vivo. Here we show that the gut bacterial metabolite phenylacetic acid (PAA…

DOI: 10.1038/s43587-025-00864-8

HCN4 channels sense temperature and determine heart rate responses to heat

DOI: 10.1038/s41467-025-57358-9

Intrapericardial injection of hydrogels with ASC and their secretome to treat dilated cardiomyopathies

DOI: 10.1038/s41598-025-87939-z

Long-term intake of Tamogi-take mushroom (Pleurotus cornucopiae) mitigates age-related cardiovascular dysfunction and extends healthy life expectancy

Abstract Age-related declines in cardiac function and exercise tolerance interfere with healthy living and decrease healthy life expectancy in older individuals. Tamogi-take mushrooms (Pleurotus cornucopiae) are known to contain high levels of Ergot…

DOI: 10.1038/s41514-024-00191-z

Maturation of human induced pluripotent stem cell-derived cardiomyocytes promoted by Brachyury priming

DOI: 10.1038/s41598-025-97676-y

Mechanotransductive stabilization of HIF-1α is inhibited by mitochondrial antioxidant therapy in the setting of pulmonary overcirculation

Abstract In patients with congenital heart disease, the development of pulmonary arterial hypertension (PAH) is based on vascular exposure to abnormal hemodynamic forces. In our work using a large animal model of increased pulmonary blood fl…

DOI: 10.1038/s41598-025-99062-0

Methylcobalamin-containing nanofiber sheets have better neuroprotective effects than small intestinal submucosa sheets

DOI: 10.1038/s41598-024-78933-y

Millimetre-scale bioresorbable optoelectronic systems for electrotherapy

DOI: 10.1038/s41586-025-08726-4

Modulation of Sel1L can alleviate altered ER homeostasis towards white matter damage in CKD-stroke complex

DOI: 10.1038/s42003-025-08100-0

Morphological and functional decline of the SNc in a model of progressive parkinsonism

Abstract The motor symptoms of Parkinson’s Disease are attributed to the degeneration of dopamine neurons in the substantia nigra pars compacta (SNc). Previous work in the MCI-Park mouse model has suggested that the loss of somatodendritic dopamine…

DOI: 10.1038/s41531-025-00873-9