High-Impact Research Publications Using ADInstruments

Bitter tastants relax the mouse gallbladder smooth muscle independent of signaling through tuft cells and bitter taste receptors

Abstract Disorders of gallbladder motility can lead to serious pathology. Bitter tastants acting upon bitter taste receptors (TAS2R family) have been proposed as a novel class of smooth muscle relaxants to combat excessive contraction in the airways and other…

DOI: 10.1038/s41598-024-69287-6

Neonatal hyperoxia exposure leads to developmental programming of cardiovascular and renal disease in adult rats

Abstract Premature infants are often exposed to hyperoxia. However, there is limited data regarding the mechanistic underpinnings linking neonatal hyperoxia exposure and its contribution to cardio-renal dysfunction in adults born preterm. Our objective was to…

DOI: 10.1038/s41598-024-65844-1

Peripheral chemoreflex restrains skeletal muscle blood flow during exercise in participants with treated hypertension

Abstract We tested the hypothesis that in human hypertension, an increased tonicity/sensitivity of the peripheral chemoreflex causes a sympathetically mediated restraint of nutritive blood flow to the exercising musc…

DOI: 10.1113/jp286998

Peripheral neural interfaces: Skeletal muscles are hyper-reinnervated according to the axonal capacity of the surgically rewired nerves

Advances in robotics have outpaced the capabilities of man-machine interfaces to decipher and transfer neural information to and from prosthetic devices. We emulated clinical scenarios where high- (facial) or low-neural capacity (ulnar) donor nerves were surgi…

DOI: 10.1126/sciadv.adj3872

Persistence of post-stress blood pressure elevation requires activation of astrocytes

Abstract The reflexive excitation of the sympathetic nervous system in response to psychological stress leads to elevated blood pressure, a condition that persists even after the stress has been alleviated. This sustained increase in blood pressure, which may…

DOI: 10.1038/s41598-024-73345-4

Pharmacokinetic and pharmacodynamic evaluation of various vasopressin doses and routes of administration in a neonatal piglet model

Abstract Epinephrine is the only recommended vasopressor during neonatal cardiopulmonary resuscitation. However, there are concerns about the potential adverse effects of epinephrine, which might hamper efficacy during c…

DOI: 10.1038/s41598-024-74188-9

Phase-separated porous nanocomposite with ultralow percolation threshold for wireless bioelectronics

DOI: 10.1038/s41565-024-01658-6

Phospholipase C-β3 is dispensable for vascular constriction but indispensable for vascular hyperplasia

Abstract Angiotensin II (AngII) induces the contraction and proliferation of vascular smooth muscle cells (VSMCs). AngII activates phospholipase C-β (PLC-β), thereby inducing Ca2+ mobilization as well as the production of reactive oxygen species (ROS). Since…

DOI: 10.1038/s12276-024-01271-6

Physiological responses of Atlantic cod to climate change indicate that coastal ecotypes may be better adapted to tolerate ocean stressors

Abstract Healthy ecosystems and species have some degree of resilience to changing conditions, however as the frequency and severity of environmental changes increase, resilience may be diminished or lost. In Sweden, one example of a species with reduced resi…

DOI: 10.1038/s41598-024-62700-0

Prenatal LPS leads to increases in RAS expression within the PVN and overactivation of sympathetic outflow in offspring rats

Abstract The renin-angiotensin system (RAS) and the sympathetic nervous system (SNS) are two major blood pressure-regulating systems. The link between the renal and cerebral RAS axes was provided by reflex activation of renal afferents and efferent sympatheti…

DOI: 10.1038/s41440-024-01754-z