Radnoti Working Heart Apparatuses

For preparations of working heart, constant flow and constant pressure Langendorff preparations.

Frequently purchased with Radnoti Working Heart Apparatuses

Overview

Radnoti isolated perfused heart systems are ideal for Working Heart and constant-flow or constant-pressure Langendorff (recirculating and non-recirculating) preparations in mice, guinea pig, rat, rabbit and cat hearts and larger, porcine hearts.

The reservoir, heart chamber, bubble traps and interconnecting tubes are water-jacketed to maintain constant temperature, with the water temperature and flow controlled by the thermo/bath circulating pump. The apparatus includes a 2 or 5 L reservoir with an oxygenating bubbler attached. A peristaltic pump drives the perfusate through a membrane oxygenator to the High-Tech Heart Chamber. A series of compliance chambers/bubble traps are included to ensure that air bubbles are removed from the perfusion system. The high-tech heart chamber has a threaded cap to ensure that the system temperature is maintained and includes access ports for stainless steel aortic and atrial cannulae, pacing electrodes and additional instrumentation. The chamber also includes a removable pulley to allow apical force measurements with an appropriate force transducer.

Please contact your ADInstruments representative for more information.

Product Configurations

Radnoti Mouse Working Heart Apparatus

Product Code
130101EZ-V

A working heart apparatus designed to mimick physiological perfusion that can maintain the cardiac function of an isolated mouse heart. Please specify V = 115 or 220 for 115V or 220V.

Radnoti Rat Working Heart Apparatus

Product Code
120101BEZ/S-V

A working heart apparatus designed to mimick physiological perfusion and maintaining the cardiac function of an isolated small animal heart. It is supplied with a small heart chamber suitable for a rat, guinea pig or small rabbit heart. Please specify the Mains Power (V) = 115 for 110-115 V or 220 for 220-240 V.

Radnoti Rabbit Working Heart Apparatus

Product Code
120101BEZ/M-V

A working heart apparatus designed to mimick physiological perfusion and maintain the cardiac function of an isolated small animal heart. It is supplied with a medium heart chamber suitable for a mid to large rabbit or cat heart. Please specify the Mains Power (V) = 115 for 110-115 V or 220 for 220-240 V

Radnoti Working Heart Apparatus for Large Animals

Product Code
140101EZ-V

For use with large hearts with high flow rates (eg. porcine hearts).

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    Related

    Research Applications

    Working Heart
    Cardiovascular Isolated Heart Systems
    In Vitro Pharmacology + Isolated Tissue and Organs
    Isolated Organ
    In Vitro Pharmacology + Isolated Tissue and Organs

    Key Features

    • One system for both Langendorff and Working Heart preparations
    • Double lumen water-jacketing insulated tubing to maintain solution temperature
    • Single-pass perfusion or recirculation modes
    • Modular construction for easy replacement of parts or updating of modified components
    • Threaded cap on High-Tech Heart Chamber minimizes temperature loss and supports cannulae
    • Color-coded system for quick setup
    • Incorporates Quick Disconnect fittings

    Support

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    Details and Tech Specs

    Technical

    Ordering information:

    When ordering the Working Heart Unit please specify:

    • The mains power voltage, where V= 115 for 110-115 mains power and 220 for 220-240 mains power.
    • Chamber size (X): S = rat, guinea pig; M = cat, rabbit.

    Product Codes

    130101EZ-V
    Radnoti Mouse Working Heart Apparatus
    120101BEZ/S-V
    Radnoti Rat Working Heart Apparatus
    120101BEZ/M-V
    Radnoti Rabbit Working Heart Apparatus
    140101EZ-V
    Radnoti Working Heart Apparatus for Large Animals