Isolated Organ
Isolated organ research allows for an organ to be studied in a controlled environment, free from external influences. Conditions such as temperature, the degree of oxygenation, available nutrients, and pH can be controlled for research purposes.
Perfusion of an organ - usually the heart, lungs, liver or kidney - may be required. Once the organ is successfully maintained outside the body, its physiological function can be studied via a whole suite of recordable parameters such as force, muscle contractions, pressure, and biopotentials.
ADInstruments offer a wide range of high-quality products, systems, and solutions to meet your isolated organ research needs, including a variety of tissue-organ bath systems. LabChart provides streamlined software to measure and analyze changes in blood pressure, flow, and volume, as well as many additional functions for pharmacological and cardiovascular research. We also offer a Dose Response Add-On, with analysis and graphical display of dose response data recorded in LabChart.
Record multiple
signals at one time
Simple, streamlined systems
you can build upon
Mix and match products for a custom solution
Integrate all your
data streams
in one place
In conjunction with our solutions shown below, any device with an analog output (+/- 10V) can be connected to a PowerLab data acquisition system for synchronization of the event in LabChart, giving you even more flexibility and the ability to integrate your data streams in one place.
All our hardware is backed by the appropriate safety certification standards. More information on safety standards.
Complete Systems or Kits
A perfusion kit that is designed to measure pH and temperature in any appropriate and meaningful location of an isolated perfusion circuit such as the Langendorff and Working Heart systems.
A foundation system that provides the glassware for perfusing an isolated rodent liver to maintain its hepatic function. The system is equipped with acquisition hardware and software for data collection and analysis of parameters including pressure, flow, and temperature.
Isolated Working Heart Systems provide all the glassware for perfusing small animal hearts, and the acquisition hardware and software for working heart data collection and analysis, including pressure, biopotentials and temperature.
Langendorff Foundation Systems that provide high quality glassware to perfuse an isolated mouse or rat heart in Langendorff mode with a versatile PowerLab and LabChart data acquisition and analysis system. Langendorff Isolated Heart Systems can be tailored to measure a number of parameters including pressure, biopotentials and temperature via a wide range of kits, available separately.
The PowerLab C Rodent Langendorff Foundation System is designed to perfuse an isolated mouse or rat heart, either in constant perfusion pressure or constant perfusion flow. Included is the high-quality, modular, yet compact ADInstruments Rodent Langendorff Apparatus, which provides flexibility for configuring various isolated heart experimental solutions. Additionally, the system is also supplied with LabChart Lightning software, flexible PowerLab C data acquisition, and hardware for measuring perfusion pressure and temperature. Further tailored parameters can be made by additionally purchasing from a range of compatible isolated heart kits, which includes measurements of left ventricular developed pressure, heart rate and biopotentials.
Related Components and Products
Data acquisition and analysis re-imagined. Make unique discoveries with unlimited freedom and flexibility.
Engineered for precise, consistent, reliable data acquisition of a wide range of physiological signals. PowerLab gives you the reproducible data you need while meeting the strictest international standards.
Creates a platform allowing you to acquire biological signals from multiple sources simultaneously and apply advanced calculations and plots.
ADInstruments Bridge Amps are single-channel or multi-channel, non-isolated bridge amplifiers designed to allow a C Series Front End Interface or traditional PowerLab to connect to most DC bridge transducers.
This digital, heated circulator allows temperature control from ambient temperature to 120°C. Ideal for the bench top.
The Masterflex® peristaltic pumps are specifically selected for their dependable and precise performance. Their design centers around a pump drive, the corresponding pump head and tubing.
For preparations of working heart, constant flow and constant pressure Langendorff preparations.
Designed to maintain cardiac function of isolated heart preparations in gravity-fed constant perfusion pressure Langendorff mode, and are available in recirculating and non-recirculating configurations. Several sizes are also available to accommodate different heart sizes including mouse, rat, guinea pig, rabbit or cat.
Designed to maintain cardiac function of isolated heart preparations in constant perfusion flow Langendorff mode, and are available in recirculating and non-recirculating configurations. Several sizes are also available to accommodate different heart sizes including mouse, rat, guinea pig, rabbit or cat.
The ADInstruments Rodent Langendorff Apparatus is relatively compact yet modular, which provides flexibility when configuring various isolated heart experimental solutions. This high-quality stainless steel and borosilicate glass apparatus includes an ADInstruments Direct Perfusion Core, which allows recirculation and reoxygenation of perfusate after priming of the apparatus, and measurements to be made close to the cannulated heart.
Transonic Flowmeters provide accurate and precise measurement of fluid volume flow in vivo, in vitro and ex vivo, which can be recorded with an Instrument Interface and/or PowerLab data acquisition systems.
A glass apparatus designed to maintain the function of an isolated rodent (mouse or rat) liver or kidney preparation, and measure up to two perfusion pressures in the perfusion circuit.
A Reservoir Filling Funnel with an in-built breather tube is designed for use with Radnoti Water Jacketed Reservoirs.
A glass chamber to be used in a Radnoti Isolated Rodent Liver/Kidney Apparatus for housing, cannulating and perfusing an isolated rodent liver/kidney.
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Flexible Data Acquisition
ADInstruments systems provide an integrated solution to advance life science research. With the combination of LabChart or LabChart Lightning analysis software and a PowerLab data acquisition unit, you have the flexibility to collect and synchronize a wide range of signals for analysis. We also offer a range of LabChart compatible solutions able to stream directly in LabChart.
LabChart data analysis software creates a platform for all of your recording devices to work together, allowing you to acquire biological signals from multiple sources simultaneously and apply advanced calculations and plots as your experiment unfolds.
Data acquisition and analysis re-imagined. Make unique discoveries with unlimited freedom and flexibility.
High-performance data acquisition hardware designed for life science research. PowerLab is engineered for precise, consistent, reliable data acquisition, giving you the reproducible data you need while meeting the strictest international safety standards.
A modular data acquisition foundation system that provides unparalleled flexibility for researchers looking to invest in customizable, reliable solutions for both now, and in the future.
All your analysis in one place
LabChart software is designed specifically for life science data and provides up to 32 channels for data display and analysis options that are powerful and easy to use. With auto-recognition of ADI and LabChart Compatible hardware, multi-window views, one touch recording, simultaneous recording from multiple devices, specialized preconfigured settings, easy sharing options and an interface that can be customized to show only the features you want to use.
Features and Add-Ons
Additional acquisition and analysis options to support your Isolated Organ analysis:
Data acquisition and analysis re-imagined.
Make unique discoveries with unlimited freedom and flexibility.
