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Working Heart

Working Heart

Working heart systems allow you to simultaneously monitor mechanical and electrical cardiac parameters, to examine the influence of preload and afterload on cardiac work during perfusion.

ADInstruments offer high-quality Working Heart and Langendorff systems for isolated working heart preparations. We also provide all complementary equipment and products, including tissue/organ baths, and a full range of supplementary accessories and consumables.

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Working Heart

Products and Solutions

Record multiple cardiac<br />
signals at one time

Record multiple cardiac
signals at one time

Complete systems<br />
available

Complete systems
available

Mix and match products<br />
for a custom solution

Mix and match products
for a custom solution

Integrate all your data<br />
streams in one place

Integrate all your data
streams in one place

Advance your cardiac investigation with ADInstruments Working Heart and Working Heart Ultimate Systems. All systems include high quality and modular Radnoti glassware, PowerLab data acquisition hardware, LabChart Pro Analysis software and high-quality components for measuring cardiac parameters. 

Add in specific amplifiers, transducers and electrodes to record atrial and aortic pressures as well as ECG or take your investigations to the next level with components such as pH and micro-oxygen probes, transonic flow meters and Millar pressure catheters, which facilitate additional cardiac parameters and oxygen consumption measurements, as well as the option to pace the heart.

In conjunction with our complete systems shown below, any device with an analog output (+/- 10V) can be connected to a PowerLab data acquisition system for synchronization of event in LabChart. So you have even more flexibility and can integrate all your data streams in one place.

All of our hardware is backed by the appropriate safety certification standards. More information on safety standards.

Complete System

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Components & Related Products

Typical Working Heart Studies

Isolated working heart preparations and organ perfusion

Medical device testing

Artificial heart development

Ischemia / Reperfusion studies

Pharmacology / toxicology studies

Systolic and diastolic dysfunction

Pulmonary hypertension

Myocardial function

Hypertrophy, infarction, cardiomyopathy and other disease models

Systemic circulation or ventricular studies

Signals Supported

Dissolved Gases
+

Measure Oxygen (O2) concentration with the ultimate working heart system and oxygen microelectrodes.

dP/dT
+

dP/dt is a signal derived from pressure, typically ventricular blood pressure, that indicates the change in pressure over time.

ECG
+

Measure Biphasic action potentials with any of our working heart systems.

Electrical Stimulation
+

Measure electrical stimulation and pacing with the ultimate working heart system and ADInstruments Stimulus Isolator.

Fluid Flow
+

Through the ultimate working heart system and Transonic Transit-Time Ultrasound Technology and flowmeters / flowsensors you can measure both atrial inflow and aortic outflow.

Heart Rate
+

Using pressure or electrical activity, monitor heart health by calculating heart rate.

pH
+

Measure pH with the ultimate working heart system and pH Amplifier.

Pressure
+

Measure parameters including perfusion/aortic pressure (afterload), dP/dt, Left ventricular pressure, left atrial pressure (preload) and developed pressure.

Temperature
+

Ensure the maintenance of a proper physiological environment in your system, or investigate the impacts of temperature on performance.

Volume
+

Using a working heart ultimate system paired with a Millar MPVS ultra foundation system you can accurately measure continuous real-time left ventricular volume directly and simultaneously with left ventricular pressure.

Flexible Data Acquisition

ADInstruments systems provide an integrated solution to advance life science research. With the combination of LabChart analysis software and a PowerLab data acquisition unit you have the flexibility to collect and synchronize a wide range of signals for analysis. We also offer a range of LabChart compatible solutions able to stream directly in LabChart.

LabChart

LabChart

Enabling Discovery

LabChart data analysis software creates a platform for all of your recording devices to work together, allowing you to acquire biological signals from multiple sources simultaneously and apply advanced calculations and plots as your experiment unfolds.

LabChart and Working Heart

PowerLab

LabChart

Data with Integrity

High-performance data acquisition hardware designed for life science research. PowerLab is engineered for precise, consistent, reliable data acquisition, giving you the reproducible data you need while meeting the strictest international safety standards.

Learn more

All your Working Heart analysis in one place

LabChart software is designed specifically for life science data and provides up to 32 channels for data display and analysis options that are powerful and easy to use. With auto-recognition of ADI and LabChart Compatible hardware, multi-window views, one touch recording, simultaneous recording from multiple devices, specialized preconfigured settings, easy sharing options and an interface that can be customized to show only the features you want to use.

  • Mouse working heart showing Aortic, atrial and LV pressues flow and dp/dt. BP analysis window of arterial pressure or aortic pressure.

    Mouse working heart showing Aortic, atrial and LV pressues flow and dp/dt. BP analysis window of arterial pressure or aortic pressure.

Benefits of Radnoti Glassware

Each working heart system includes easy to assemble Radnoti glassware that can be easily adapted for a range of studies. 

  • Modular design allows for extreme flexibility and system reconfigurations
  • Complete water-jacketed glassware and tubing for superb temperature control
  • Powerful Thermal Bath/Circulator provides start-up to 37°C in 15 minutes with excellent accuracy
  • Hi-tech heart chamber with threaded cap and access ports for easy insertion of cannulae and probes
  • Quick and easy disassembly with quick-disconnect tubing
  • Independently adjustable preload and afterload pressure
  • Single pass perfusion or recirculation modes for experiment flexibility
  • Fully autoclavable crystal clear borosilicate glassware

Radnoti Glassware is also provided in all Radnoti Langendorff Systems - (Contact Pressure or Flow) ×

Features and Add-Ons

Additional acquisition and analysis features and add-ons to support your Working Heart studies:

Explore Working Heart Data in LabChart Reader

LabChart Reader is a free application for conducting limited analyses of LabChart data. Download a trial package with example data below.

Platform Required

Thanks! Your trial package is now downloading.

Once downloaded, please unzip the folder and install the LabChart Reader application.

Open the "LabChart Data Files" folder to find data files (".adicht"). Data files can be opened in LabChart Reader by double clicking on the file name.

Request a demo

Thank you for your interest in Working Heart. Please complete and submit the form below and an ADInstruments representative will aim to get in touch within one working day. If you’d like to speak to someone immediately, office contact information is available from the contact page.

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Ask a question

Thank you for your interest in Working Heart. Please complete and submit the form below and an ADInstruments representative will aim to get in touch within one working day. If you’d like to speak to someone immediately, office contact information is available from the contact page.

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Ask a question×