High-Impact Research Publications Using ADInstruments

Cholesterol metabolism and neuroinflammatory changes in a non-human primate spinal nerve ligation model

DOI: 10.1038/s41598-025-96160-x

Renal nerves and hypertension contribute to impaired proximal tubule megalin-mediated albumin uptake in renovascular hypertensive rats

DOI: 10.1038/s41440-025-02100-7

Respiratory long COVID in aged hamsters features impaired lung function post-exercise with bronchiolization and fibrosis

Abstract Long-term consequences of SARS-CoV-2 infection affect millions of people and strain public health systems. The underlying pathomechanisms remain unclear, necessitating further research in appropriate animal mode…

DOI: 10.1038/s41467-025-57267-x

Sex‐specific characterization of aortic function and inflammation in a new diet‐induced mouse model of metabolic syndrome

Abstract Perivascular adipose tissue (PVAT) expansion promotes inflammation and vascular dysfunction in metabolic syndrome (MetS), but the sexual dimorphisms of PVAT are poorly understood. Using a new mouse model of diet…

DOI: 10.1096/fj.202401871r

Shikimic acid protects against doxorubicin-induced cardiotoxicity in rats

Abstract Doxorubicin (DOX) is used to treat a variety of malignancies; however, its cardiotoxicity limits its effectiveness. Shikimic acid (SA) showed several promising biomedical applications. This study investigated th…

DOI: 10.1038/s41598-025-90549-4

SNAP25-dependent membrane trafficking of the Kv1.5 channel regulates the onset of atrial fibrillation

DOI: 10.1038/s41467-025-59096-4

Stem cells prevent long-term deterioration of renal function after renal artery revascularization in a renovascular hypertension model in rats

DOI: 10.1038/s41598-025-87451-4

Subnanomolar MAS-related G protein-coupled receptor-X2/B2 antagonists with efficacy in human mast cells and disease models

Abstract The MAS-related G protein-coupled receptor-X2 (MRGPRX2), an orphan receptor expressed on mast cells (MCs), is upregulated upon inflammation and induces hypersensitivity and inflammatory diseases. In contrast to the large number of MRGPRX2 a…

DOI: 10.1038/s41392-025-02209-8

Sympathetic nervous system inhibition enhances cardiac metabolism and improves hemodynamics and glucose-insulin dynamics in obese and lean rat models

DOI: 10.1038/s41598-024-84218-1

The sonic hedgehog signaling inhibitor cyclopamine improves pulmonary arterial hypertension via regulating the bone morphogenetic protein receptor 2 pathway

DOI: 10.1038/s41598-025-97627-7