Can the Millar MPVS Ultra system be used to record PV data from the right ventricle in small and large animals?

As clinical interest in right heart dysfunction and its effect on overall cardiovascular health has increased, a growing number of researchers are studying right ventricle (RV) pressure volume (PV) loops with the Millar MPVS Ultra system in both small and large animals. Because RV PV is a relatively new area of research, there are a limited number of publications currently available (see the links to selected citations listed below). 

In order to account for the differences in RV loops compared to left ventricle (LV) loops, ADInstruments introduced two new algorithms into the PV Loop Module 2.5 . These new algorithms provide improved, automatic detection of end-systole for both right and left ventricular PV loops as well as in situations where LV PV loops may take on a more 'triangular' shape. A video explaining the changes can be found HERE .

Note: Due to the geometry of the RV in some animals (e.g. mice), there are limitations in obtaining accurate absolute volume measurements when using the MPVS Ultra system. The system was not initially intended to be used to measure RV PV data in small animals as the RV is not as cylindrical in shape when compared to the LV for recording accurate volume measurements. However, some researchers have obtained promising RV PV Loop Data with the MPVS Ultra system (see the linked LabChart files listed below). 

For further technical assistance with this or any other issue, please contact ADInstruments Technical Support by clicking HERE.