PV Loop

PV Loop 2.5: For left and right ventricle studies.

LabChart’s latest version of the PV Loop Analysis Module includes new features designed to give you precise and accurate measurements of right and left ventricular contractility in rats, mice and other animals. In version 2.5, we have added two new algorithms for detecting end-systole in both right and left ventricular PV loops, and in situations where your PV loop may take on a more 'triangular' shape.

Ventricular pressure-volume (PV) loops are the gold standard method for measuring direct, real-time complete cardiac function, particularly myocardial contractility measurements. PV loops can be generated by plotting real-time ventricular pressure against ventricular volume during a complete cardiac cycle.

The PV Loop Analysis Module provides instant cardiovascular function feedback based on morphology, position and timing of the loop, supporting a range of cardiovascular research areas such as:

• Systolic and diastolic dysfunction
• Valvular heart disease
• Cardiomyopathy
• Pulmonary hypertension
• Cardiac failure
• Cardiovascular remodelling and vascular occlusions
• Transgenic manipulation
• Ischemia / Reperfusion studies
• Cardiac resynchronization therapy

In combination with Millar’s extensive range of PV catheters - you have a highly sensitive, and minimally invasive way to measure and analyze changes in ventricular pressure-volume in small and large animals.

The PV Loop Analysis Software offers smart presets for different animals and streamlined workflows guiding you step-by-step from calibration through to analysis.

What's new in PV Loop 2.5?

• Added a new single-beat detection method ‘Sinusoidal pressure fit’.
• Added single-beat ESPVR (end-systolic pressure-volume relationship) into the hemodynamics table.
• Added single-beat Piso (max pressure of an isovolumic beat) into the hemodynamics table.
• Added a new ‘Loop tangent fit’ method for calculating ESPVR and the End Systolic points from multiple beats during occlusions.

Note: the Sinusoidal pressure fit’ and ‘Loop tangent fit’ methods are especially useful for right ventricle measurements and other situations where the PV loop has a ‘triangular’ shape.

How to download PV Loop 2.5

The PV Loop Module is included as part of LabChart Pro or can be purchased separately. You can download the PV Loop Module using LabChart's Feature Manager, or on our website: PV Loop 2.5 for Windows.

System Requirements

 PV Loop 2.5 is only compatible with LabChart v8.1.13 or later.

Get the most out of your data by combining the PV-loop Analysis Module with some additional LabChart Modules such as:

ECG Analysis - automatically detects and reports PQRST onset, amplitude and intervals in real time, or after recording.

HRV - the R-wave threshold detector identifies and calculates ECG beat-to-beat interval variation to automatically categorize beats as normal, ectopic, or artifact (can also be used with arterial pulse signal).

Peak Analysis - provides automatic detection and analysis of multiple, non-overlapping signal peaks.

Blood Pressure - blood pressure graphing, monitoring & tracking software - automatically reporting cardiovascular parameters from arterial or ventricular pressure signals.

Cardiac Output - calculate the cardiac output of small animals, such as rats and mice, using the thermodilution technique.