Mouse PV Catheters
Overview
Millar Pressure-Volume (PV) catheters have revolutionized cardiovascular research in small animals. These ultra-miniature catheters are capable of measuring left ventricular pressure and volume simultaneously and continuously from the intact, beating hearts of mice. Built to the highest quality standards, the catheters combine a proven Mikro-Tip® pressure sensor with four electrodes to collect real-time pressure-volume data, enabling minimally invasive, continuous, intracardiac PV analysis.
Each contains four platinum electrodes arranged in two pairs. The paired electrodes are separated by 0.5 mm, while the distance between the pair varies between catheters. The pressure sensor is located in the center, between the two pairs of electrodes.
They can be used with:
- MPVS Ultra Foundation Systems
- MPVS Ultra Single Segment Pressure-Volume Unit
- MPVS-400 Pressure-Volume Unit (replaced by MPVS Ultra Single Segment Pressure-Volume Unit)
MPVS PV-Units require the MPVS Ultra Cable Pack (purchased separately).
Calibration: A Pressure Gauge kit that provides the necessary items to calibrate the pressure transducers is available. The PV Loop Add-On for LabChart provides step-by-step Workflows to guide you through the calibration process.
Millar Mikro-Tip Catheters require a certain level of care to ensure accuracy and the anticipated lifespan of your catheters. Tergazyme (Alconox, Inc.) is required for cleaning and ensuring the removal of proteinaceous soils, tissue, blood and body fluids from the catheter. Please refer to Alconox, Inc.’s website to purchase from your local supplier. For a few best practice tips to help get you started with your catheters, see our guide here. Additionally, the purchase of an ESD Adjustable Wrist Strap w/ 10’ Coil Cord (Blue, 4mm Snap) is highly recommended to protect these catheters from electrostatic discharge (ESD) damage during handling.
Non-repairable discount options are available for the Mouse PV Catheter (SPR-839 only). Contact us to find out more and if this is the right option for you.
Product Configurations
Mouse PV Catheter (1.1F, 4E, 3.0mm, 3.5cm, PI, Non Repairable)
This PV catheter's length (3.5 cm), diameter (1.1F), and electrode spacing (3.0 mm) are optimal for ventricular volume measurement in smaller mice, and for right ventricle measurements.
For standard-sized animals, the the Mouse PV Catheter (1.1F, 4E, 4.5 mm, 3.5 cm, PI, Non Repairable) is recommended.
Mouse PV Catheter (1.1F, 4E, 3.5mm, 3.5cm, PI, Non Repairable)
This PV catheter's length (3.5 cm) and electrode spacing (3.5 mm) are optimized for ventricular volume measurement in smaller mice (< 25 g), and for right ventricle measurements. The smaller diameter (1.1F) of the catheter minimizes obstruction of blood flow in the vessel and allows improved surgical access to the right ventricle and pulmonary arteries.
For standard-sized animals, the Mouse PV Catheter (1.1F, 4E, 4.5 mm, 3.5 cm, PI, Non Repairable) is recommended.
Mouse PV Catheter (1.1F, 4E, 4.5mm, 4.5cm, PI, Non Repairable)
This PV catheter's length (3.5 cm) and electrode spacing (4.5 mm) are optimized for ventricular volume measurement in standard-sized mice (25 g or greater). The 1.1F diameter of the catheter material minimizes the obstruction of blood flow in the vessel and allows for improved surgical access, which enables the use of smaller, younger mice for earlier detection of disease or treatment.
Mouse PV Catheter (1.4F, 4E, 4.5mm, 3.5cm, PI)
This Polyimide Mikro-Tip pressure-volume catheter for normal/large mice has a 3.5 cm effective length with a pressure sensor (1.4F) and four electrodes (electrode spacing 4.5 mm). The pressure sensor is centered between E2 & E3. Catheter body is 0.8F. It should be used with the MPVS-Ultra Foundation System. The SPR-839 is reusable and can be repaired.
Related
Products
Research Applications
Cardiovascular Hemodynamics
Working Heart
Cardiovascular Isolated Heart Systems
In Vitro Pharmacology + Isolated Tissue and Organs
Key Features
- Ultra-miniature 1.1-1.4 F catheters, each housing a pressure sensor.
- Pressure and volume measurement from a single instrument.
- Flexible, durable catheter material (Polyimide Nylon).
- No motion artifact or damping of pressure signal.
- Pressure measurement at the source.
- High frequency response.
Applications:
These catheters combine pressure sensors and electrodes for simultaneous, high-fidelity pressure and volume measurements, enabling minimally invasive, continuous, intracardiac PV analysis.
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Details and Tech Specs
Technical
| Model number | Length (cm) | Tip (French) | No. sensors | Electrode spacing | Use-life | Repairable |
|---|---|---|---|---|---|---|
| PVR-1030 | 3.5 | 1.1 | 1 | 3 mm | Reusable - Non-Sterile | no |
| PVR-1035 | 3.5 | 1.1 | 1 | 3.5 mm | Reusable - Non-Sterile | no |
| PVR-1045 | 3.5 | 1.1 | 1 | 4.5 mm | Reusable - Non-Sterile | no |
| SPR-839 | 3.25 | 1.4 | 1 | 4.5 mm | Reusable - Non-Sterile | yes |
