Kaha Sciences fully implantable rat and mouse telemetry solutions combine state of the art technologies to provide unrivaled accuracy and long-term recording in neuroscience research.
With options to measure physiological pressures, biopotentials, sympathetic nerve activity, and tissue oxygen concentrations, 24/7 over the course of your experiment - Kaha Sciences telemeters allow you to measure a range of physiological signals to meet your research needs.
Below we have outlined some unique neuroscience applications using Kaha Sciences telemeters, plus some of the benefits they provide over other available technologies.
Kaha Sciences Telemetry – Neuroscience applications:
Kaha Sciences rat pressure telemeters use the Millar Mikro-Tip® solid-state sensor technology, at the catheter tip to accurately measure small pressures, repeatably and with high fidelity. The 2 Fr (0.66 mm) sensor can be implanted in the epidural or subdural space for measurement of intracranial pressure. Telemeters are available with single 25cm catheters (TRM54P), dual catheters (TRM54PP), or in combination with a biopotential channel (TRM54PB).
- Thakkar, P. et al. Hypertensive Response to Ischemic Stroke in the Normotensive Wistar Rat: Mechanisms and Therapeutic Relevance. Stroke 50, 2522–2530 (2019).
- Kawoos, U et al. Protective Effect of N-Acetylcysteine Amide on Blast-Induced Increase in Intracranial Pressure in Rats. Frontiers in Neurology, 8, 219 (2017)
Monitoring pathophysiological activity, such as epileptic seizure, in vivo has traditionally been challenging due to the spontaneous nature of the condition. Kaha Sciences’ innovative use of wireless power technology has removed the compromise of battery-life to allow users to record continuously at a high sampling rate (2kHz) over long-term experiments.
The reusable rat biopotential telemeters give users the option to record a single EEG channel (TR50B) or combine EEG and nuchal EMG recordings (TR50BB), while our mouse telemeters (MT10B) allow the recording of EEG along with activity. The ability to record continuously ensures that more data is captured and fewer seizure events are missed.
- Hill, A. C., et al. Correction of medication nonadherence results in better seizure outcomes than dose escalation in a novel preclinical epilepsy model of adherence. Epilepsia 60 (3), 475-484 (2019).
- Read, M. I., et al. Atenolol offers better protection than clonidine against cardiac injury in kainic acid‐induced status epilepticus. British Journal of Pharmacology 172 (19), 4626-4638 (2016).
The ability to capture data in real-time, 24/7 is invaluable in studying normal physiological rhythms over long experimental time courses. Using the Kaha Sciences rat (TR50B and TR50BB) and mouse (MT10B) biopotential telemeters it’s possible to record EEG or EMG and identify different stages in the sleep/wake cycle.
Alternatively, users can benefit from the full range of Kaha telemeters to investigate ultradian or circadian rhythms in physiological parameters and how these might change in disease.
The TR57Y tissue oxygen telemeter is the only device available on the market that can measure long-term tissue oxygen concentration from conscious rats, in real-time. The telemeter uses a stable carbon paste electrode and can measure local ischemia and tissue metabolic activity in the brain or kidney. Combined with our wireless power technology researchers have been able to assess circadian variability in kidney tissue oxygen thanks to the ability to record 24/7.
- Adamovich, Y. et al. Oxygen and Carbon Dioxide Rhythms Are Circadian Clock Controlled and Differentially Directed by Behavioral Signals. Cell Metab. 29, 1092-1103.e3 (2019).
- Russel, D, M. et al. A fully implantable telemetry system for the chronic monitoring of brain tissue oxygen in freely moving rats Journal Article. Journal of Neuroscience Methods, 204 (2), 242-248 (2012)
The TRM56SP telemeters allow users to simultaneously record SNA and blood pressure to give an insight into the autonomic control of cardiovascular physiology. The input range of the SNA leads is ±60µV making it ideal for activity recording from fine, peripheral autonomic nerves studies in studies of stress, cardiovascular control and the development of hypertension.
- McBryde, F. D., Liu, B. H., Roloff, E. V., Kasparov, S. & Paton, J. F. R. Hypothalamic paraventricular nucleus neuronal nitric oxide synthase activity is a major determinant of renal sympathetic discharge in conscious Wistar rats. Physiol. 103, 419–428 (2018).