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  • Blog (27)
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Why is the end systolic volume (ESV) larger than the end diastolic volume (EDV) in the PV-Loop Module's Hemodynamics table?

Support Article
… This temporally mis-aligns the pressure and volume data, and causes the LabChart PV-Loop Module to incorrectly identify the EDV and ESV values. For further technical …
ECG Analysis LabChart Software

ECG Analysis

Product
… as normal, ectopic, or artifact (can also be used with arterial pulse signal). PV Loop  - specifically designed for the analysis of in vivo ventricular pressure-volume …
Image

Ventricular Pressure Volume + PV Loops

Research Application
… on safety standards. Surgical Instruction Video Series: Pressure Volume (PV) and Invasive Pressure ADInstruments has been working alongside surgical expert …
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Where can I learn more about the surgical, data acquistion, and data analysis techniques used in Pressure-Volume loop experiments?

Support Article
… Video Series  HERE  covers many surgical procedures needed for Pressure Volume (PV) and Invasive Pressure studies. The Millar Knowledge Center, accessed HERE , is a great resource for learning the background of the Pressure-Volume (PV) loop experiment and surgical and analysis techniques. It is free to use and only …
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Can the Millar MPVS Ultra system be used to record PV data from the right ventricle in small and large animals?

Support Article
… growing number of researchers are studying  right ventricle (RV) pressure volume (PV) loops with the Millar MPVS Ultra system  in both small and large animals. Because RV PV is a relatively new area of research, there are a limited number of publications … left ventricle (LV) loops, ADInstruments introduced two new algorithms into the PV Loop Module 2.5 . These new algorithms provide improved, automatic detection of …
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When recording PV-Loop data, why is the subject's pressure signal and heart rate lower than expected?

Support Article

The animal is either over-anesthetized or has lost too much blood during the course of the surgical procedure. Adjust the anesthesia concentration and/or dosage, or choose a more appropriate anesthetic agent. Minimize blood loss during surgery by...

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Frequently asked questions about cardiac pressure-volume (PV) loop studies

Documentation
… support specialists on frequently asked questions about cardiac pressure-volume (PV) loop studies. Please note, the following questions were asked during our webinar on Cardiac PV Loop Data Analysis: Tips and Tricks . See here to watch the webinar …
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How is aortic stenosis characterized by left ventricle pressure volume loops?

Support Article
… the contraction's force to maintain stroke volume.  Aortic stenosis will cause PV loops to shift up and to the right.   For further technic al assistance with this …
Image

Introduction to PV loops: Understanding points on the PV loop and measures of cardiac function

Blog
… Pressure-volume (PV) loops are the gold standard for measuring direct, real-time cardiac function. By … simultaneously plotting real-time ventricular pressure against ventricular volume, PV loops provide a unique, quantitative approach for determining the contractility of … University School of Medicine, provides a comprehensive introduction to the PV loop, how it compares to other techniques, and tips for interpreting measures of …
video

PV Loop 2.5 Update

Video
… Great news! LabChart’s latest version of the PV Loop Analysis Module includes new features designed to give you precise and accurate … two new algorithms for detecting end-systole in both right and left ventricular PV loops, and in situations where your PV loop may take on a more 'triangular' shape. …
pressure volume loop labchart

PV Tips and Tricks: Expert advice for measuring pressure-volume loops in mice

Blog
… Variability in your pressure-volume (PV) measurements can be introduced at any stage of the experiment, from your catheter … your experimental design, plus handy tips and tricks for collecting high-quality PV loop data. Overview Fluid management   - Blood loss and insensible fluid loss …
image

Ventricular Pressure-Volume + PV Loops

Page
… Ventricular Pressure Volume + PV Loops The gold-standard for measuring direct, real-time, complete cardiac function. Ventricular Pressure Volume Loops (PV Loops) provide direct, real-time data about load-independent cardiac function. … Pressure Support Ventricular Pressure-Volume Support Contact Us Advantages of PV Loop Research ADInstruments and Millar PV Loop System Real Results in Research …
video

Optimizing Preclinical PV Loop Techniques and Analysis in Mice

Video
… started with Pressure-Volume acquisition and analysis, or those already using PV Loops who may benefit from tips on increasing throughout and experimental … connection and setup; through to an introduction to the Labchart workflow for PV and how to optimize workflow from acquisition of PV Loops to how to analyze them … to PV assessments: Including compliance and inotropy / interpreting the loop Surgical procedure setup: Including preparation tips, equipment setup and …
video

Cardiac PV Loop Data Analysis: Tips & Tricks (Webinar)

Video
…   This is a useful webinar for cardiovascular researchers who currently use PV Loops and would like to improve, or those who are interested in exploring PV loops for future cardiovascular research. Abstract: During this session, PV loop experts DeWayne Townsend, DVM, PhD and Adam Goodwill, PhD discuss how to collect …
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What catheter volume segment length do I use for particular animal models with the Millar MPVS Duo?

Support Article
… Millar MPVS Duo interface. The segment being used will be displayed on the “New PV Loop Protocol: Optimize Catheter Position” screen shown below.     A Ventri-Cath … that span different ventricular scenarios.      If you see an odd shape in your PV loops, the most likely reason is if the volume sensing segment is not placed …
Four catheters and the title 'Should you be using admittance or conductance calibration for PV Loops?'

Should you be using Admittance or Conductance calibration for PV Loops?

Blog
… Pressure-volume (PV) loops are the gold standard for measuring direct, real-time cardiac function. By … simultaneously plotting real-time ventricular pressure against ventricular volume, PV loops provide a unique, quantitative approach for determining the contractility of … measurement forms the basis for the volume measurement.  Image A pressure-volume loop graphs pressure against volume within the ventricle to produce a …
2024-Chris West Heart Spine PV Loop

Associate Professor Chris West: The heart, the spine, and the PV loop

Blog
… performance from the load on the heart. This is the reason Chris and his team use PV loops. Related: Introduction to PV loops: Understanding points on the PV loop and measures of cardiac function “With typical cardiac measures you have to ask …
video

Calibration and Setup of your MPVS Ultra (using PV Loop module)

Video
… animals large and small. Proper configuration is paramount to running a successful PV experiment. Join David as he discusses the proper steps for configuring a typical … hardware and software setup using the multisegment catheters, cables and Ultra PV system. David will also discuss how to properly use the built-in volume … techniques using Rho cuvette and Baan’s equation. Utilizes the specialized PV Loop Analysis Module in LabChart.    Click here for information on the MPVS Duo >> …
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Can I use the Rho Cuvette with my MPVS Duo?

Support Article
… using Bahn’s equation, which will require the Rho value to be entered into the PV workflow in LabChart's PV Loop Module to get a suitable readout that was previously applied in the MPVS Ultra …
Image

Keeping Cardiovascular Researchers in the Loop: Why studying pressure-volume loops could be useful for you...

Blog
… researcher? Find out why you should consider studying ventricular pressure-volume (PV) loops - the gold standard for measuring direct, real-time cardiac function. Why study PV Loops? Pressure-volume loops are the gold standard for measuring direct, real-time … severity, prognosis and response to therapies in patients with PH.   Analyzing PV Loop data - The problem with right ventricular PV loops Analyzing PV loop data is …

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