×

Isolated Tissue Baths

Isolated Tissue Baths

Isolated tissue baths are used to maintain the integrity of muscle tissue for several hours, in a controlled environment, while physiological measurements are performed.

Controlling conditions like temperature, oxygenation, nutrients and pH is a useful way to observe and compare evoked responses to drugs and electrical stimulation. The tissue responds to the stimuli by contracting or relaxing, and an isometric or isotonic transducer is used to measure force or displacement, respectively. A wide a variety of tissue from various species can be studied, including chick, toad, rabbit, rat, mouse and guinea-pig.

PowerLab and LabChart, combined with a tissue bath apparatus, provide a simple, sophisticated solution for Isolated Tissue Research.

Ask a Question Book a Demo

Isometric contraction analysis of a toad rectus muscle to the presence of acetylcholine and suxamethonium using Dose Response Module

Products and Solutions

Record multiple<br />
signals at one time

Record multiple
signals at one time

Simple, streamlined systems<br />
you can build upon

Simple, streamlined systems
you can build upon

Mix and match products for a custom solution

Mix and match products for a custom solution

Integrate all your<br />
data streams<br />
in one place

Integrate all your
data streams
in one place

In conjunction with our solutions shown below, any device with an analog output (+/- 10V) can be connected to a PowerLab data acquisition system for synchronization of the event in LabChart, giving you even more flexibility and the ability to integrate your data streams in one place.

All our hardware is backed by the appropriate safety certification standards. More information on safety standards.

Complete System

Click the Quote Request icon to add
a product to your Quote Request

×

Components & Related Products

Typical Studies using Isolated Tissue Baths

Pharmacological discovery studies

Determining the effects of drugs

Drug therapy studies

Molecular modeling of drugs

Pharmacological dissection of cell function

Muscle fatigue and performance

Isolated tissue experiments and research

In vitro tissue response

Signals Supported

Electrical Stimulation
+

Measure electrical stimulation and pacing for your in vitro research.

Fluid Flow
+

Fluid flow can be recorded in isolated tissue and organ research.

Force
+

Force can be measured in isolated tissue and organ research.

Temperature
+

Temperature is a useful tool in determining many factors such as subject health or the stability of an experimental preparation. It is also usefulas a calculation factor for comparing measurements taken in different states.

Flexible Data Acquisition

ADInstruments systems provide an integrated solution to advance life science research. With the combination of LabChart analysis software and a PowerLab data acquisition unit you have the flexibility to collect and synchronize a wide range of signals for analysis. We also offer a range of LabChart compatible solutions able to stream directly in LabChart.

LabChart

LabChart

Enabling Discovery

LabChart data analysis software creates a platform for all of your recording devices to work together, allowing you to acquire biological signals from multiple sources simultaneously and apply advanced calculations and plots as your experiment unfolds.

LabChart and Isolated Tissue Baths

PowerLab

LabChart

Data with Integrity

High-performance data acquisition hardware designed for life science research. PowerLab is engineered for precise, consistent, reliable data acquisition, giving you the reproducible data you need while meeting the strictest international safety standards.

Learn more

All your Isolated Tissue Baths analysis in one place

LabChart software is designed specifically for life science data and provides up to 32 channels for data display and analysis options that are powerful and easy to use. With auto-recognition of ADI and LabChart Compatible hardware, multi-window views, one touch recording, simultaneous recording from multiple devices, specialized preconfigured settings, easy sharing options and an interface that can be customized to show only the features you want to use.

  • Isometric contraction analysis of a toad rectus muscle to the presence of acetylcholine and suxamethonium using Dose Response Module

    Isometric contraction analysis of a toad rectus muscle to the presence of acetylcholine and suxamethonium using Dose Response Module

Important principles to observe when performing tissue bath experiments.

  • First, tissue sources and availability should be weighed against the experimental requirements because time of tissue harvesting and viability may be significantly impacted.

  • Second, the tissue anatomy needs to be understood, especially where it determines the direction of contraction and relaxation because it will then determine the correct tissue orientation within its chamber.

  • Third, when first developing or establishing a preparation, it is always recommended to have a series of positive and negative controls to determine how well the preparation is functioning, in part or in whole. These controls may be mechanical, pharmacological or physiological in nature.

  • ×

    Features and Add-Ons

    Additional acquisition and analysis features and add-ons to support your Isolated Tissue Baths studies:

    Explore Isolated Tissue Baths Data in LabChart Reader

    LabChart Reader is a free application for conducting limited analyses of LabChart data. Download a trial package with example data below.

    Platform Required

    Thanks! Your trial package is now downloading.

    Once downloaded, please unzip the folder and install the LabChart Reader application.

    Open the "LabChart Data Files" folder to find data files (".adicht"). Data files can be opened in LabChart Reader by double clicking on the file name.

    Videos

    Training

    Request a demo

    Thank you for your interest in Isolated Tissue Baths. Please complete and submit the form below and an ADInstruments representative will aim to get in touch within one working day. If you’d like to speak to someone immediately, office contact information is available from the contact page.

    ×

    Ask a question

    Thank you for your interest in Isolated Tissue Baths. Please complete and submit the form below and an ADInstruments representative will aim to get in touch within one working day. If you’d like to speak to someone immediately, office contact information is available from the contact page.

    ×