Easily detect gas thresholds with graphical aids like LabChart's Guide Lines and the DVM mini window, and use the Event Manager Add-On to automate the detection of gas thresholds.
With the Langendorff isolated heart perfusion technique you can monitor an isolated heart while perfusing the coronary arteries with a nutrient solution. This allows you to record and analyze multiple cardiac parameters such as left ventricular developed pressure, perfusion pressure, cardiac electrical activity, heart rate and temperature all in real time.
ADInstruments' solutions support your use of the Langendorff animal heart perfusion technique to perfuse all sizes of heart models, from mice, rats, and guinea pigs, to porcine hearts.
In conjunction with our complete Langendorff perfusion systems shown below, any device with an analog output (+/- 10V) can be connected to a PowerLab data acquisition system for synchronization of event in LabChart. So you have even more flexibility and can integrate all your data streams in one place.
All of our hardware is backed by the appropriate safety certification standards. More information on safety standards.
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Isolated heart and organ perfusion
Medical device testing
Artificial heart development
Ischemia / Reperfusion studies
Pharmacology / toxicology studies
Myocardial function
Hypertrophy, infarction, cardiomyopathy and other disease models
Systemic circulation or ventricular studies
Coronary vessel function
Easily detect gas thresholds with graphical aids like LabChart's Guide Lines and the DVM mini window, and use the Event Manager Add-On to automate the detection of gas thresholds.
dP/dt is a signal derived from pressure, typically ventricular blood pressure, that indicates the change in pressure over time.
Cardiac electrical activity from the myocardium can be monitored to assess myocardial damage to electrophysiological workings of the heart.
Using pressure or electrical activity, monitor heart health by calculating heart rate.
Coronary perfusion pressure and left ventricular developed pressure can be monitored during an isolated heart session to gauge myocardial performance.
Ensure the maintenance of a proper physiological environment in your system, or investigate the impacts of temperature on performance.
ADInstruments systems provide an integrated solution to advance life science research. With the combination of LabChart or LabChart Lightning analysis software and a PowerLab data acquisition unit, you have the flexibility to collect and synchronize a wide range of signals for analysis. We also offer a range of LabChart compatible solutions able to stream directly in LabChart.
Enabling Discovery
LabChart data analysis software creates a platform for all of your recording devices to work together, allowing you to acquire biological signals from multiple sources simultaneously and apply advanced calculations and plots as your experiment unfolds. Learn more about LabChart and Langendorff »
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Data with Integrity
High-performance data acquisition hardware designed for life science research. PowerLab is engineered for precise, consistent, reliable data acquisition, giving you the reproducible data you need while meeting the strictest international safety standards. Learn more »
Re-engineered for
unparalleled flexibility
A modular data acquisition foundation system that provides unparalleled flexibility for researchers looking to invest in customizable, reliable solutions for both now, and in the future. Learn more »
LabChart software is designed specifically for life science data and provides up to 32 channels for data display and analysis options that are powerful and easy to use. With auto-recognition of ADI and LabChart Compatible hardware, multi-window views, one touch recording, simultaneous recording from multiple devices, specialized preconfigured settings, easy sharing options and an interface that can be customized to show only the features you want to use.
'Perfusion pressure' and 'aortic pressure' are two terms used to describe one of the pressure parameters in a Langendorff Heart experiment.
To measure aortic pressure in a Langendorff heart preparation the perfusate in the perfusate reservoir is typically gassed with 95% O2 and 5% CO2 for at least 30 minutes. The perfusate then flows into the aorta of the heart via a 3-way tap. The catheter of the pressure transducer is also connected to the 3-way tap, which allows constant measurement of the perfusion/aortic pressure.
×Additional acquisition and analysis features and add-ons to support your Langendorff studies:
Thank you for your interest in Langendorff. Please complete and submit the form below and an ADInstruments representative will aim to get in touch within one working day. If you’d like to speak to someone immediately, office contact information is available from the contact page.
×Thank you for your interest in Langendorff. Please complete and submit the form below and an ADInstruments representative will aim to get in touch within one working day. If you’d like to speak to someone immediately, office contact information is available from the contact page.
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