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Langendorff

Langendorff

With the Langendorff technique you can monitor an isolated heart while perfusing the coronary arteries with a nutrient solution. This allows you to record and  analyze multiple cardiac parameters such as left ventricular developed  pressure, perfusion pressure, cardiac electrical activity, heart rate and temperature all in real time.  

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Langendorff

Products and Solutions

Record multiple<br />
signals at one time

Record multiple
signals at one time

Compact and modular options available

Compact and modular options available

Mix and match products<br />
for a custom solution

Mix and match products
for a custom solution

Integrate all your data<br />
streams in one place

Integrate all your data
streams in one place

  • Perfuse all sizes of heart models hearts from mice, rats and guinea pigs, to porcine hearts
  • Choose from a compact system which utilises a peristaltic pump and STH pump controller for constant flow and pressure or more traditional modular system
  • Maintain constant temperature with a heater water bath, water jacketed tubing, components and heart chamber
  • Easily switch between constant-pressure and constant flow modes to investigate coronary artery function while the heart beats spontaneously or with the help of an external stimulator

In conjunction with our complete systems shown below, any device with an analog output (+/- 10V) can be connected to a PowerLab data acquisition system for synchronization of event in LabChart. So you have even more flexibility and can integrate all your data streams in one place.

All of our hardware is backed by the appropriate safety certification standards. More information on safety standards.

Complete System

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Components & Related Products

Typical Langendorff Studies

Isolated heart and organ perfusion

Medical device testing

Artificial heart development

Ischemia / Reperfusion studies

Pharmacology / toxicology studies

Myocardial function

Hypertrophy, infarction, cardiomyopathy and other disease models

Systemic circulation or ventricular studies

Coronary vessel function

Signals Supported

Dissolved Gases
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Easily detect gas thresholds with graphical aids like LabChart's Guide Lines and the DVM mini window, and use the Event Manager Add-On to automate the detection of gas thresholds.

Products related to Dissolved Gases and Langendorff

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dP/dT
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dP/dt is a signal derived from pressure, typically ventricular blood pressure, that indicates the change in pressure over time.

Products related to dP/dT and Langendorff

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ECG
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Cardiac electrical activity from the myocardium can be monitored to assess myocardial damage to electrophysiological workings of the heart.

Products related to ECG and Langendorff

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Heart Rate
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Using pressure or electrical activity, monitor heart health by calculating heart rate.

Products related to Heart Rate and Langendorff

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Pressure
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Coronary perfusion pressure and left ventricular developed pressure can be monitored during an isolated heart session to gauge myocardial performance.

Products related to Pressure and Langendorff

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Temperature
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Ensure the maintenance of a proper physiological environment in your system, or investigate the impacts of temperature on performance.

Products related to Temperature and Langendorff

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Flexible Data Acquisition

ADInstruments systems provide an integrated solution to advance life science research. With the combination of LabChart analysis software and a PowerLab data acquisition unit you have the flexibility to collect and synchronize a wide range of signals for analysis. We also offer a range of LabChart compatible solutions able to stream directly in LabChart.

LabChart

LabChart

Enabling Discovery

LabChart data analysis software creates a platform for all of your recording devices to work together, allowing you to acquire biological signals from multiple sources simultaneously and apply advanced calculations and plots as your experiment unfolds.

LabChart and Langendorff

PowerLab

LabChart

Data with Integrity

High-performance data acquisition hardware designed for life science research. PowerLab is engineered for precise, consistent, reliable data acquisition, giving you the reproducible data you need while meeting the strictest international safety standards.

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All your Langendorff analysis in one place

LabChart software is designed specifically for life science data and provides up to 32 channels for data display and analysis options that are powerful and easy to use. With auto-recognition of ADI and LabChart Compatible hardware, multi-window views, one touch recording, simultaneous recording from multiple devices, specialized preconfigured settings, easy sharing options and an interface that can be customized to show only the features you want to use.

  • Typical 'lang' recording highlighting LVP, ECG, perfusion pressure and calculated variables. The Blood Pressure Add-On analyzes ventricular pressure waveforms for you.

    Typical 'lang' recording highlighting LVP, ECG, perfusion pressure and calculated variables. The Blood Pressure Add-On analyzes ventricular pressure waveforms for you.

Measuring aortic pressure in a Langendorff Heart preparation

'Perfusion pressure' and 'aortic pressure' are two terms used to describe one of the pressure parameters in a Langendorff Heart experiment.

To measure aortic pressure in a Langendorff heart preparation the perfusate in the perfusate reservoir is typically gassed with 95% O2 and 5% CO2 for at least 30 minutes. The perfusate then flows into the aorta of the heart via a 3-way tap. The catheter of the pressure transducer is also connected to the 3-way tap, which allows constant measurement of the perfusion/aortic pressure. 

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Features and Add-Ons

Additional acquisition and analysis features and add-ons to support your Langendorff studies:

Langendorff Data in LabChart

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Ask a question

Thank you for your interest in Langendorff. Please complete and submit the form below and an ADInstruments representative will aim to get in touch within one working day.
If you’d like to speak to someone immediately, office contact information is available from the contact page.

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Request a demo

Thank you for your interest in Langendorff. Please complete and submit the form below and an ADInstruments representative will aim to get in touch within one working day.
If you’d like to speak to someone immediately, office contact information is available from the contact page.

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