Langendorff Isolated Heart Perfusion Systems

Record multiple
signals at one time

Compact and modular options available

Mix and match products
for a custom solution

Integrate all your data
streams in one place

Our Langendorff perfusion systems provide everything you need for isolated heart research:

• Perfuse all sizes of isolated hearts from mice, rats and guinea pigs, to porcine hearts
• Choose from a compact perfusion system which utilises a peristaltic pump and STH pump controller for constant flow and pressure or more traditional modular isolated heart apparatus
• Maintain constant temperature with a heater water bath, water jacketed tubing, components and heart chamber
• Easily switch between constant-pressure and constant flow modes to investigate coronary artery function while the heart beats spontaneously or with the help of an external stimulator

In conjunction with our complete Langendorff perfusion systems shown below, any device with an analog output (+/- 10V) can be connected to a PowerLab data acquisition system for synchronization of event in LabChart. So you have even more flexibility and can integrate all your data streams in one place.

All of our hardware is backed by the appropriate safety certification standards. More information on safety standards.

Resources for Isolated Tissue-Organ System Success

What is an Isolated Heart Perfusion System?

An isolated heart perfusion system is specialized research apparatus designed to maintain and study a heart outside the body in a controlled physiological environment. The Langendorff technique remains the gold standard for ex vivo cardiac research, allowing scientists to study heart function, drug effects, and disease mechanisms in isolation from systemic influences.

A complete Langendorff perfusion system typically includes:

• Perfusion apparatus with oxygenating chamber and bubble trap for delivering warmed, oxygenated perfusate to the isolated heart through retrograde aortic cannulation
• Temperature-controlled water bath and jacketed glassware to maintain physiological temperature (typically 37°C)
• Heart chamber with cannula mounting for secure positioning and observation
• Pressure transducers and balloon catheters for measuring left ventricular developed pressure, perfusion pressure, and dP/dt
• Data acquisition system (PowerLab) with LabChart software for real-time recording and analysis of cardiac parameters

ADInstruments offers complete isolated heart perfusion systems through our Radnoti glassware range, designed for various species from mouse to larger animal models. Each perfusion system integrates seamlessly with PowerLab data acquisition for synchronized recording of pressure, ECG, temperature, and flow measurements.