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Ventricular Pressure Volume + PV Loops

Ventricular Pressure Volume + PV Loops

Changes in ventricular function for both normal and diseased conditions can be studied through analysis of ventricular pressure volume loops. The gold standard method for measuring direct, real-time complete cardiac function, particularly myocardial contractility measurements, PV loops can be generated by plotting real-time left or right ventricular pressure against ventricular volume during a complete cardiac cycle.

Providing instant cardiovascular function feedback based on morphology, position and timing of the loop, ventricular pressure volume is the only research technique that provides you full diastolic analysis and allows you to vary the load and measure beat-to-beat response of that changing load in cardiac performance.

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Ventricular Pressure Volume + PV Loops

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Products and Solutions

Gold standard<br /> catheters

Gold standard
catheters

Begin with a<br /> foundation system<br /> and build from there

Begin with a
foundation system
and build from there

Mix and match<br /> products for a<br /> custom solution

Mix and match
products for a
custom solution

Integrate all<br /> your data streams<br /> in one place

Integrate all
your data streams
in one place

We are  proud to be exclusive global distributors of Millar Mikro-Tip®  pressure catheters and associated hardware for ventricular pressure volume recording. By combining these highly sensitive, minimally invasive  catheters with the power and integrity of PowerLab data acquisition and LabChart data analysis software, you can be sure you’ll get results you can trust.

Learn more about Millar

In conjunction with our solutions shown below, any device with an analog output (+/- 10V) can be connected to a PowerLab data acquisition system for synchronization of events in LabChart. So you have even more flexibility and can integrate all your data streams in one place.

All of our hardware recommended for human use is backed by the appropriate safety certification standards. More information on safety standards.

Foundation Systems

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Components & Related Products

Typical Ventricular Pressure Volume Studies

Systolic and diastolic dysfunction

Pulmonary hypertension

Cardiac hypertrophy

Cardiac failure

Cardiovascular remodelling and vascular occlusions

Pharmacology / toxicology studies

Transgenic manipulation

Ischemia / Reperfusion studies

Gene manipulations

Cardiac resynchronization therapy

Surgical interventions

Signals Supported

dP/dT
+

dP/dt is a signal derived from pressure, typically ventricular blood pressure, that indicates the change in pressure over time.

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ECG
+

Millar Mikro-Tip PV catheters are also able to measure intercardiac ECG from the MPVS Ultra System when placed inside the left ventricle of an animal. The peak of the R wave aligns with end-diastolic pressure in the left ventricle which may be used to enhance the analysis settings of LabChart’s PV Module.

More info »

Pressure
+

Accurately measure continuous real-time left ventricular blood pressure directly and simultaneously with left ventricular volume .  at the source using a range of Millar Mikro-Tip PV catheters and system options. With PV loop analysis a wide array of hemodynamic parameters can be gathered for assessment of complete cardiac function.

More info »

Volume
+

Accurately measure continuous real-time left ventricular blood volume directly and simultaneously with left ventricular pressure  at the source using a range of Millar Mikro-Tip PV catheters and system options. With PV loop analysis a wide array of hemodynamic parameters can be gathered for assessment of complete cardiac function. 

More info »

Surgical Instruction Video Series

Surgical Instruction Video Series: Pressure Volume (PV) and Invasive Pressure

ADInstruments has been working alongside surgical expert Prof. René Remie, to produce a series of step-by-step instructional videos that demonstrate common Pressure-Volume and Invasive Pressure catheterization procedures.

Each of the 5 videos in the series follows a surgical catheterization procedure from start to finish, and include helpful techniques and tips throughout.

These videos are a unique and valuable resource for researchers performing cardiovascular research in animal models.

See video series

Flexible Data Acquisition

ADInstruments systems provide an integrated solution to advance life science research. With the combination of LabChart or LabChart Lightning analysis software and a PowerLab data acquisition unit, you have the flexibility to collect and synchronize a wide range of signals for analysis. We also offer a range of LabChart compatible solutions able to stream directly in LabChart.

LabChart

LabChart

Enabling Discovery

LabChart data analysis software creates a platform for all of your recording devices to work together, allowing you to acquire biological signals from multiple sources simultaneously and apply advanced calculations and plots as your experiment unfolds. Learn more about LabChart and Ventricular Pressure Volume + PV Loops »

LabChart Lightning LabChart Lightning

Data acquisition and analysis re-imagined. Make unique discoveries with unlimited freedom and flexibility. Try LabChart Lightning »

PowerLab

PowerLab

Data with Integrity

High-performance data acquisition hardware designed for life science research. PowerLab is engineered for precise, consistent, reliable data acquisition, giving you the reproducible data you need while meeting the strictest international safety standards. Learn more »

PowerLab C

PowerLab C

Re-engineered for
unparalleled flexibility

A modular data acquisition foundation system that provides unparalleled flexibility for researchers looking to invest in customizable, reliable solutions for both now, and in the future. Learn more »

All your analysis in one place

LabChart software is designed specifically for life science data and provides up to 32 channels for data display and analysis options that are powerful and easy to use. With auto-recognition of ADI and LabChart Compatible hardware, multi-window views, one touch recording, simultaneous recording from multiple devices, specialized preconfigured settings, easy sharing options and an interface that can be customized to show only the features you want to use.

  • Inferior vena cava (IVC) occlusion data from a rat featuring the Loop View, PRSW Plot, and Hemodynamics Table from LabChart’s PV Loop Analysis Add-On.

    Inferior vena cava (IVC) occlusion data from a rat featuring the Loop View, PRSW Plot, and Hemodynamics Table from LabChart’s PV Loop Analysis Add-On.

  • Real time monitoring of Ventricular Pressure and Volume signals, Arterial pressure, and dP/dt calculated using cyclic measurements

    Real time monitoring of Ventricular Pressure and Volume signals, Arterial pressure, and dP/dt calculated using cyclic measurements

  • An IVC occlusion, featuring typical analysis plots such as Preload-recruitable stroke work and load dependent mechanical work

    An IVC occlusion, featuring typical analysis plots such as Preload-recruitable stroke work and load dependent mechanical work

Features and Add-Ons

Additional acquisition and analysis features and add-ons to support your Ventricular Pressure Volume + PV Loops studies:

PV Loop LabChart Pro
+

Analyze left or right ventricular pressure and volume baseline and occlusion data in realtime or post acquisition. PV Loop offers smart presets for large and small animals and streamlined workflow guiding you step-by-step from calibration through to analysis. 

More info »

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PV Loop

MLS375/8

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Blood Pressure LabChart Pro
+

Automatically detects, analyzes, and reports cardiovascular parameters from arterial or ventricular pressure signals in real time or post acquisition. 

More info »

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Blood Pressure

MLS370/8

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Analysis Manager
+

Used in conjunction with LabChart Modules to save the module settings associated with one or more analyses

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Analysis Manager

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Pro Tip
Pro Tip: Caring for your Millar Mikro-Tip® Catheters

Caring for your Millar Mikro-Tip® Catheters

Millar Mikro-Tip Catheters require a certain level of care to ensure accuracy and the anticipated lifespan of your catheters. For a few best practice tips to help get you started with your catheters, see our guide here.

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LabChart Lightning
LabChart Lightning
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Data acquisition and analysis re-imagined.

Make unique discoveries with unlimited freedom and flexibility.

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Videos

01:06:46

Cardiac PV Loop Data Analysis: Tips & Tricks (Webinar)

PV Loop experts DeWayne Townsend, DVM, PhD and Adam Goodwill, PhD will discuss the equipment...

05:40

Understanding the Importance of PV Catheter Calibration in Admittance and Conductance Systems

Pressure-Volume (PV) Loops are the gold standard for measuring direct,...

Pages

 

Training

Application Workshops

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Live Product Demonstrations

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Personalized Training

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Software Training

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Surgical Training

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Webinars

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Training »

Related Support Articles

Understanding the Importance of PV Catheter Calibration in Admittance and Conductance Systems
Cardiac PV Loop Data Analysis: Tips & Tricks (Webinar)
Understanding Ventricular Pressure-Volume Catheter Calibrations and Experimental Design
Frequently asked questions about cardiac pressure-volume (PV) loop studies
Can the ADInstruments PV-Loop Module be used with an admittance catheter system?
more

Related Application Areas

Invasive Blood Pressure

Invasive Blood Flow

Thermodilution / CO

Peripheral Circulation

Autonomic Research (Animal)

Tissue and Circulation (Animal)

Pharmacology

Surgical Equipment and Monitoring

See all Cardiovascular applications »

Citations

3,900 papers

in Ventricular Pressure Volume + PV Loops on Google Scholar cite ADInstruments.

Pál Pacher, Takahiro Nagayama, Partha Mukhopadhyay, Sándor Bátkai & David A Kass, Measurement of cardiac function using pressure–volume conductance catheter technique in mice and rats

Marcello Tontodonati, Debbie Ridley, René Remie, Peter Clements, Improved method for the catheterization of the right ventricle in a rat model of pulmonary artery hypertension

Gabriele G. Schiattarella, Francisco Altamirano, Dan Tong, Kristin M. French, Elisa Villalobos, Soo Young Kim, Xiang Luo et al., Nitrosative stress drives heart failure with preserved ejection fraction

Related Blog Articles

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Testimonial

For several years I have worked with LabChart and Powerlab, taking advantage of their pressure-volume system and applying it to right ventricular function. The system has always performed perfectly, with easy to use, and yet detailed analysis. Using their system we are able to perform hours of continuous acquisitions per animal, and with the new LabChart Workflow, analysis has become much smoother and quicker. I would advise any researcher wanting to study cardiovascular physiology to use ADInstruments.

Dr. Pedro Ferreira

University of Porto, Portugal

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Thank you for your interest in Ventricular Pressure Volume + PV Loops. Please complete and submit the form below and an ADInstruments representative will aim to get in touch within one working day. If you’d like to speak to someone immediately, office contact information is available from the contact page.

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