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Optogenetics

Optogenetics

Optogenetics is a relatively recent technique which uses light to precisely manipulate neural activity (neuromodulation). It involves transfecting targeted cells with an opsin (photosensitive protein) and exciting or silencing them with pulses of visible light. Compared to conventional electrical stimulation, optogenetics reduces the activation of neighbouring cells ensuring that stimulation is highly targeted and results in specific physiological and behavioural effects.

The Kaha Sciences Optogenetics telemeter from ADInstruments is the first fully implantable, controllable optogenetics stimulator for use in rats that can also record biopotential (EEG, ECG, EMG) signals. An ideal solution for chronic and therapeutic research applications including heart pacing, seizure suppression and reducing abnormal motor symptoms. This telemeter allows researchers to apply extended optogenetic stimulation protocols and record quantitative biopotential data in long-term experiments without the restrictions of battery power and tethers.

EEG showing seizure in a mouse

Products and Solutions

Wireless - power and data recording

Wireless - power and data recording

High fidelity<br />
signals

High fidelity
signals

Simultaneous stimulation<br /> and recording

Simultaneous stimulation
and recording

24/7 continuous<br /> recording

24/7 continuous
recording

Advantages of Telemetry Based Optogenetics

Despite significant advances in the transfection of channelrhodopsins into specific cell types, the technology for the provision of light for stimulation traditionally relies on tethered or head mounted systems. Advantages that telemetry based optogenetics studies have over these alternative methods make this the ideal option for chronic and therapeutic research studies.

Conscious – Anesthesia affects most physiological control systems and can significantly confound your results. Telemetry allows data to be collected from conscious animals after they have recovered from surgery and enables cognitive and behavioral studies not possible under anesthesia.

Unrestrained – Restraining animals induces stress which affects normal physiological functions and the data recorded. Telemetry allows data collection from animals in their home cage without the stress induced by the presence of researchers or handling. The lack of tethers also reduces maintenance/ replacement burden.

Long-term – Offers truly chronic recording over days, weeks or months. Researchers can develop stimulation protocol while studying biological rhythms and follow the development of pathology as it occurs. Within animal design strengthens the statistical power of a study and can reduce group sizes.

Fully Implantable - The full surgical implantation of telemeters and animal recovery process prior to recording ensures there are no exposed wounds or sites for possible infections, improving animal welfare.

Quality Data - Reduced noise and movement artefacts from amplifiers being so close to the point of measurement and no external tether acting as an aerial to attract noise.

More of the advantages of telemetry

Advantages of Kaha Sciences Telemetry
Extensively used globally in academic and research institutions as well as biotechnology and pharmaceutical companies, Kaha systems combine high fidelity digital telemetry with patented wireless power technology to create high-quality solutions for your physiological monitoring needs. Paired with PowerLab and LabChart/LabChart Lightning, this solution sets the new standard in quality and power for implantable, wireless telemetry in rats and mice. Measure true high-fidelity signals such as ventricular and arterial pressures, sympathetic nerve activity (SNA), biopotentials (e.g. ECG, EMG & EEG), tissue oxygen, and optogenetics stimulating and recording.

Learn more about Kaha Sciences

In conjunction with our solutions shown below, any device with an analog output (+/- 10V) can be connected to a PowerLab data acquisition system for synchronization of the event in LabChart, including other implantable items (vascular access ports, osmotic pumps, infusion pumps). This gives you even more flexibility and the ability to integrate your data streams in one place.

Typical Studies

Parkinson's Disease

Epilepsy

Cardiac Dysfunction

Depression

Addiction

Pain

Retina Degeneration

Auditory Dysfunction

Flexible Data Acquisition

ADInstruments systems provide an integrated solution to advance life science research. With the combination of LabChart or LabChart Lightning analysis software and a PowerLab data acquisition unit, you have the flexibility to collect and synchronize a wide range of signals for analysis. We also offer a range of LabChart compatible solutions able to stream directly in LabChart.

LabChart

LabChart

Enabling Discovery

LabChart data analysis software creates a platform for all of your recording devices to work together, allowing you to acquire biological signals from multiple sources simultaneously and apply advanced calculations and plots as your experiment unfolds. Learn more about LabChart and Optogenetics »

Data acquisition and analysis re-imagined. Make unique discoveries with unlimited freedom and flexibility. Try LabChart Lightning »

PowerLab

PowerLab

Data with Integrity

High-performance data acquisition hardware designed for life science research. PowerLab is engineered for precise, consistent, reliable data acquisition, giving you the reproducible data you need while meeting the strictest international safety standards. Learn more »

PowerLab C

PowerLab C

Re-engineered for
unparalleled flexibility

A modular data acquisition foundation system that provides unparalleled flexibility for researchers looking to invest in customizable, reliable solutions for both now, and in the future. Learn more »

All your analysis in one place

LabChart software is designed specifically for life science data and provides up to 32 channels for data display and analysis options that are powerful and easy to use. With auto-recognition of ADI and LabChart Compatible hardware, multi-window views, one touch recording, simultaneous recording from multiple devices, specialized preconfigured settings, easy sharing options and an interface that can be customized to show only the features you want to use.

  • EEG showing seizure in a mouse

    EEG showing seizure in a mouse

Features and Add-Ons

Additional acquisition and analysis features and add-ons to support your Optogenetics studies:

Simultaneously sample and compare telemetry data with other physiological signals.

One of the great features of combining DSI PhysioTel™ Implants with LabChart is the ability to simultaneously sample from a PowerLab. Your data is synchronized  (+-20ms) with your telemetry implants, allowing you to combine implanted signals with other physiological parameters such as respiratory signals.

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LabChart Lightning
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Make unique discoveries with unlimited freedom and flexibility.

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Thank you for your interest in Optogenetics. Please complete and submit the form below and an ADInstruments representative will aim to get in touch within one working day. If you’d like to speak to someone immediately, office contact information is available from the contact page.

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Thank you for your interest in Optogenetics. Please complete and submit the form below and an ADInstruments representative will aim to get in touch within one working day. If you’d like to speak to someone immediately, office contact information is available from the contact page.

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