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PV Loop

MLS375/8

PV Loop

Pressure Volume (PV) Loop Analysis Software

PRICE ON REQUEST

Product code: MLS375/8

The PV Loop Analysis Software Module for LabChart is specifically designed for the analysis of in vivo ventricular pressure-volume data in small and large animals, or ex vivo, using working heart systems. Analyze ventricular pressure-volume baseline and occlusion data in realtime or post acquisition.

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Overview

Understanding Ventricular Pressure-Volume Catheter Calibrations and Experimental Design

Ventricular pressure-volume (PV) loops are the gold standard method for measuring direct, real-time complete cardiac function, particularly myocardial contractility measurements. PV loops can be generated by plotting real-time left ventricular pressure against left ventricular volume during a complete cardiac cycle.

The PV Loop Analysis Module provides instant cardiovascular function feedback based on morphology, position and timing of the loop, supporting a range of cardiovascular research areas such as:

  • Systolic and diastolic dysfunction
  • Valvular heart disease
  • Cardiomyopathy
  • Pulmonary hypertension
  • Cardiac failure
  • Cardiovascular remodelling and vascular occlusions
  • Transgenic manipulation
  • Ischemia / Reperfusion studies
  • Cardiac resynchronization therapy

In combination with Millar’s extensive range of PV catheters - you have a highly sensitive, and minimally invasive way to measure and analyze changes in ventricular pressure-volume in small and large animals.

Related

Nature Protocol - Measurement of cardiac function using pressure–volume conductance catheter technique in mice and rats

Best Practice Tips - Millar Pressure and Pressure Volume Catheters

The PV Loop Analysis Software offers smart presets for different animals and streamlined workflows guiding you step-by-step from calibration through to analysis.

The PV Loop Module is included as part of LabChart Pro or can be purchased separately.

Get the most out of your data by combining the PV-loop Analysis Module with some additional LabChart Modules such as:

ECG Analysis - automatically detects and reports PQRST onset, amplitude and intervals in real time, or after recording.

HRV - the R-wave threshold detector identifies and calculates ECG beat-to-beat interval variation to automatically categorize beats as normal, ectopic, or artifact (can also be used with arterial pulse signal).

Peak Analysis - provides automatic detection and analysis of multiple, non-overlapping signal peaks.

Blood Pressure - blood pressure graphing, monitoring & tracking software - automatically reporting cardiovascular parameters from arterial or ventricular pressure signals.

Cardiac Output - calculate the cardiac output of small animals, such as rats and mice, using the thermodilution technique.

Features

Loop View

  • Choose which PV loops to analyze
  • Contractility index using ESPVR slope (linear or quadratic)
  • Compliance index using EDPVR slope (linear or exponential)

Industry Standard Parameters

  • Stroke Work, Cardiac Output, Ejection Fraction, Tau Isovolumic Relaxation Constant, and many more
  • Available from the Haemodynamics Table, with support for exporting to LabChart DataPad, or csv/text files for analysis

Analysis Plots

  • Preload-recruitable stroke work (PRSW)
  • Preload-recruitable maximum pressure change (dP/dt Max vs. EDV)
  • Preload-recruitable maximum pressure change (dP/dt Max vs. EDV)
  • Preload-recruitable total mechanical work (PVA vs. EDV)
  • Afterload-dependent total mechanical work (PVA vs. ESP)

Streamlined Workflow

PV Loop guides your journey from pressure, conductance and volume calibration through to data analysis with supporting workflows for large animals, small animals, or echocardiogram users.

Intelligent Presets

Preset calibrations for small and large mammals enable you to follow best practices for recording and analyzing PV data using Millar catheters. The Workflow modes are optimized for use with the MPVS Ultra Foundation Systems.

Powerful Volume Calibration

PV Loop also supports the analysis of multiple averaged cuvette well readings for accurate conductance to volume calibration.

Parallel Conductance Averaging

Correcting for parallel conductance from multiple saline bolus infusions doesn't need to be difficult. You can now generate a Ves Ved regression curve using averaged data to give you a reliable estimate.

Advanced Calibration

Alpha calibration is supported for researchers validating ventricular derived cardiac output with an independent measure, e.g., using a Transonic flow probe.

Support

Support Articles

Our Support Articles contain answers to common questions, how-tos, solutions, and documentation.

Training and Workshops

Maximize time and resources with our customized training services delivered at your facility, on your equipment, on your terms.

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Details and Tech Specs

Product Code

MLS375/8
PV Loop

Technical

Compatibility

LabChart 8 for Windows checkmark
LabChart 8 for Mac -

Software Downloads

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