Understanding Ventricular Pressure-Volume Catheter Calibrations and Experimental Design
Ventricular pressure-volume (PV) loops are the gold standard method for measuring direct, real-time complete cardiac function, particularly myocardial contractility measurements. PV loops can be generated by plotting real-time left ventricular pressure against left ventricular volume during a complete cardiac cycle.
The PV Loop Analysis Module provides instant cardiovascular function feedback based on morphology, position and timing of the loop, supporting a range of cardiovascular research areas such as:
- Systolic and diastolic dysfunction
- Valvular heart disease
- Pulmonary hypertension
- Cardiac failure
- Cardiovascular remodelling and vascular occlusions
- Transgenic manipulation
- Ischemia / Reperfusion studies
- Cardiac resynchronization therapy
In combination with Millar’s extensive range of PV catheters - you have a highly sensitive, and minimally invasive way to measure and analyze changes in ventricular pressure-volume in small and large animals.
Nature Protocol - Measurement of cardiac function using pressure–volume conductance catheter technique in mice and rats
Best Practice Tips - Millar Pressure and Pressure Volume Catheters
The PV Loop Analysis Software offers smart presets for different animals and streamlined workflows guiding you step-by-step from calibration through to analysis.
The PV Loop Module is included as part of LabChart Pro or can be purchased separately.
Get the most out of your data by combining the PV-loop Analysis Module with some additional LabChart Modules such as:
ECG Analysis - automatically detects and reports PQRST onset, amplitude and intervals in real time, or after recording.
HRV - the R-wave threshold detector identifies and calculates ECG beat-to-beat interval variation to automatically categorize beats as normal, ectopic, or artifact (can also be used with arterial pulse signal).
Peak Analysis - provides automatic detection and analysis of multiple, non-overlapping signal peaks.
Blood Pressure - blood pressure graphing, monitoring & tracking software - automatically reporting cardiovascular parameters from arterial or ventricular pressure signals.
Cardiac Output - calculate the cardiac output of small animals, such as rats and mice, using the thermodilution technique.