Isolated heart - Langendorff

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Isolated heart - Langendorff

Overview

Record isolated heart parameters with the Langendorff system.

Achieve continuous recording of multiple cardiac parameters such as Left Ventricular Pressure and Vascular resistance with a complete Langendorff system.  

Langendorff recording showing ventricular pressure waveforms in a rat heart displayed using LabChart

Typical 'lang' recording highlighting LVP, ECG, perfusion pressure and calculated variables. The Blood Pressure Add-On analyzes ventricular pressure waveforms for you.

Hardware

Choose from a compact Langendorff system which utilises a peristaltic pump and STH pump controller to achieve a constant flow or constant pressure, or a more traditional modular Langendorff system.  Dedicated amplifiers, transducers and electrodes along with the PowerLab Data Acquisition system allow simultaneous measurements if mechanical and electrical cardiac parameters as well as temperature monitoring.

Software

  • Use LabChart features to calculate real-time Heart Rate, Left Ventricular Developed Pressure (LVDP) and dP/dT measurements.
  • Use the Blood Pressure Add-On to calculate parameters from ventricular pressure signals and the ECG Analysis Add-On to detect and report on PQRST intervals and amplitudes.
  • Simultaneously monitor multiple cardio-mechanic and cardio-energetic parameters as well as ECG signals. Use LabChart’s Dose Response Add-On to automate valuable calculations including EC50 and Hill slopes.

Featured Citation

Sutherland FJ, Shattock MJ, Baker KE & Hearse DJ (2003). Mouse isolated perfused heart: characteristics and cautions. Clin Exp Pharmacol Physiol 30: 867-878.

Citations

1,840

Isolated heart - Langendorff papers on Google Scholar cite ADInstruments.

Solutions

LabChart Module

Dose Response

Centralized setup and display. Custom or automatic calculation and generation of single or multiple dose response curves.

Complete System

Langendorff Systems

Designed to perfuse isolated small animal hearts such as mouse, rat and guinea pig using the Langendorff Heart technique, while providing measurement of pressure, biopotentials and temperature.

LabChart Module

Peak Analysis

Automate calculation of peak parameters such as peak height, half-width, latency period, population spike height, rise time, area and tau.

Products

LabChart

Flexible data acquisition and analysis software.


PowerLab

Multi-purpose data acquisition hardware.