A merger of expertise, 
technology, and purpose.

Clarity and flexibility for your isolated heart and tissue research

Radnoti Glassware

For over 40 years, Radnoti has been a trusted producer of fine glass instruments and turn-key systems for the life science research community.

  • Superior quality, customization and consistency - Radnoti delivers unmatched craftsmanship, flexible system design, long-term value, and performance you can rely on.
  • Clear visualization of the perfusion circuit - vital to isolated heart research for air bubble removal and identification of potential foreign material.
  • Fully autoclavable and easy to clean - designed for hassle-free sterilization and long-term use.
  • Scratch resistant and chemically resilient - unaffected by agents and proteins, ensuring lasting clarity.
  • Water-jacketed perfusion designs - provide steady and efficient temperature control throughout your experiments.
  • Long-term reliable investment - built to last with high-quality materials and proven design trusted by researchers worldwide.

The True Cost of a Langendorff System - a Comparative Guide

Setting the standard

The unique combination of premium crystal clear Radnoti glassware, modular and robust instruments, and state of the art data acquisition and analysis with PowerLab and LabChart creates a system unsurpassed in quality, finish, and user experience. This provides more efficient and effective tools for your research laboratory - engineered for performance and built to last.

Isolated heart

Never miss a beat with our powerful Langendorff and Working Heart research systems. Whether you want to monitor mechanical and electrical cardiac parameters without the influence of other physiological processes, record atrial and aortic pressures, or examine the influence of preload and afterload on cardiac work, our systems can support your research with simple set up, flexible recording, and powerful analysis.

Isolated Tissue

Our Tissue-Organ Bath Systems are the gold standard in pharmacological isolated tissue research and are frequently cited in research papers and validation studies. The high quality glassware and the modular systems allow you to easily add and substitute components. Unique features such as the water-jacketed perfusate tubing and glassware reflect the attention to detail and functionality synonymous with Radnoti.

Radnoti

Radnoti is now a brand of ADInstruments NZ Ltd.

 ADInstruments gives researchers access to a trusted global sales and support network with over 35 years of industry experience.

Manufacturing of glass componentry will remain with the existing operational team so that customers can continue to expect the same level of high quality product as they have always received.

Radnoti Products

Complete Systems and Kits

Instruments

Glassware Components

Transducers

Accessories and Spare Parts

Proven within the research community

  • Metabolic reprogramming by immune-responsive gene 1 upregulation improves donor heart preservation and function Ienglam Lei, Wei Huang, Pierre Emmanuel Noly, Suyash Naik, Miriyam Ghali, Liu Liu, Francis D Pagani, Ashraf Abou El Ela, Jordan S Pober, Bertram Pitt, Jeffrey L Platt, Marilia Cascalho, Zhong Wang, Y Eugene Chen, Richard M Mortensen, Paul C Tang Science Translational Medicine, 15(682), 2023

    Age, Sex and Overall Health, Measured As Frailty, Modify Myofilament Proteins in Hearts From Naturally Aging Mice Alice E. Kane, Elise S. Bisset, Kaitlyn M. Keller, Anjali Ghimire, W. Glen Pyle, Susan E. Howlett Scientific Reports, 10(1), 2020

    Hyperresponsiveness to inhaled but not intravenous methacholine during acute respiratory syncytial virus infection in mice Rachel A Collins, Rosa C Gualano, Graeme R Zosky, Constance L Atkins, Debra J Turner, Giuseppe N Colasurdo & Peter D Sly Respiratory Research, 6(1), 2005

    Multiple Mass Isotopomer Tracing of Acetyl-CoA Metabolism in Langendorff-perfused Rat Hearts: Channeling of Acetyl-CoA from Pyruvate Dehydrogenase to Carnitine Acetyltransferase Qingling Li, Shuang Deng, Rafael A. Ibarra, Vernon E. Anderson, Henri Brunengraber, and Guo-Fang Zhang Journal of Biological Chemistry, 290(13), 2015

  • An Isolated Working Heart System for Large Animal Models Matthew A. Schechter, Kevin W. Southerland, Bryan J. Feger, Dean Linder Jr., Ayyaz A. Ali, Linda Njoroge, Carmelo A. Milano, Dawn E. Bowles Journal of Visualized Experiments, 2014

    Cardiac Toxicity of Azole Antifungals John D. Cleary, Kayla R. Stover, Jerry Farley, William Daley, Patrick B. Kyle, Jon Hosler Pharmacology & Pharmacy, 04(03), 2013

    A Model for Normothermic Preservation of the Rat Liver H Tolboom, R Pouw, K Uygun, Y Tanimura, M-L Izamis, F Berthiaume, M L. Yarmush Tissue Engineering, 13(8), 2007

 
 

Go Beyond the Standard Approach with LabChart

With LabChart analysis software, your research questions drive the analysis options, not the other way around. Providing the perfect balance of ease, flexibility and power, LabChart allows you to acquire signals from multiple sources simultaneously and apply advanced calculations as your experiment unfolds.

  • Getting started with LabChart is straight-forward and user-friendly meaning the learning curve for new users is much lower.
  • You can choose to either use a range standard analysis tools like cyclic measurements, spectrum, channel calculations, data pad; or you can easily customize macros specific to your own unique research requirements to provide flexibility in your study design.
  • LabChart tracks every action you take while never modifying your raw data, ensuring the integrity of your results so you can focus on the true insights of your research.
  • Flexibility via PowerLab to add other analog signals such as gas analysis, spirometry, stimulation and cystometry into your research with confidence.

Learn more about LabChart

Related LabChart Add-Ons

Dose Response

The Dose Response Software Module allows analysis and graphical display of dose response type data recorded in LabChart.

Event Manager

The Event Manager Add-On for LabChart monitors incoming signals, detects user-defined events, and performs associated user-defined actions.

Peak Analysis

The Peak Analysis Module for LabChart provides automatic detection and analysis of multiple, non-overlapping, signal peaks.

HRV

The Heart Rate Variability (HRV) Module for LabChart analyzes beat-to-beat interval variation in ECG recordings or arterial pulse signals.

ECG Analysis

The ECG (EKG) Analysis Module for LabChart automatically detects and reports PQRST onset, amplitude and intervals in real time, or after recording.

Blood Pressure

The Blood Pressure Module for LabChart acts as a blood pressure graphing, monitoring & tracking software, automatically reporting cardiovascular parameters from arterial or ventricular pressure signals.
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Blogs and Case Studies

A Langendorff designed for the long-term

FREE DOWNLOAD: A comparative guide to Langendorff Systems. The redesign of our Rodent Langendorff Apparatus focussed on functionality, modularity, and a system that would continue to perform long-term. Learn more about how the ADInstruments Langendorff system compares to others on the market.

From Cyanide to CBD - March 2025 High Impact Publications

Here at ADInstruments, we're lucky to be a part of a large and thriving research community. Join us in celebrating some of the incredible work published by that community in March.

Prolonged liver viability and the Welsh Advanced Neuroimaging Database - February 2025 High Impact Publications

Join us in celebrating some of the incredible work published by that community over the past few months.

Bitter Tastes, Antidepressants, and a Cardiac Stimulator - Five High Impact Publications from August 2024

In this month's high impact publications, we touch on: an injectable cardiac stimulator, the relationship between the gallbladder and bitter tastes, protein prenylation inhibition for prevention of renal fibrosis, sustained cerebrovascular responses after learning a new motor skill, and the use of SSRIs for muscle stem cell regeneration.

Introducing our new Lab Builder!

Try out our new Lab Builder! A no-obligation tool designed to help you identify the equipment you need.

Dr Lei Fan: Computational Modeling and the Working Heart

Dr Lei Fan looks at the heart as a whole, quantifying and modeling the mechanical forces acting upon it in each heartbeat. Focusing on cardiovascular disease, Lei and her team in The FAN Lab collect data from in-vivo and ex-vivo experiments and then model the heart based on that data to see how disease develops, and how to best optimize treatments.

How Dr. Lei Fan improved confidence and efficiency in her cardiovascular research lab

Meet Dr. Lei Fan and learn about her experience receiving onsite training for the Working Heart Apparatus We spoke with Dr. Lei Fan, Director of The FAN Lab and Assistant Professor in the Joint Department of Biomedical Engineering at Marquette University and the Medical College of Wisconsin...

New Video: How to easily set-up and prime the Rodent Langendorff Apparatus

Watch Mark de Reus, Head of Support walk-through video of setting-up and priming our new Rodent Langendorff Apparatus.

Dr Melanie White's Favourite Features of the Rodent Langendorff

In this excerpt from her latest Langendorff webinar, Dr Melanie White, an isolated heart expert from the University of Sydney, explores her favorite features of the Rodent Langendorff and Direct Perfusion Core.

Which isolated heart study is right for you?

Ever wondered what the difference is between a Myocyte Isolation, Langendorff, and a Working Heart perfusion model? You’re not the only one! Download our free guide.

Dr Melanie White - Modernising the Langendorff

Over the past 200 years the Langendorff has continued to evolve. In this excerpt from her latest Langendorff webinar, Dr Melanie White, an isolated heart expert from the University of Sydney, explores how the system has significantly changed in the time she's been running her lab. Related: Future...

Radnoti is now an ADInstruments brand

Clarity and flexibility for your isolated heart and tissue research.

Dr Melanie White - The History and Principles of Langendorff

Explore the history of the Langendorff apparatus with this excerpt from Dr Melanie White's recent webinar.

Top 10 Cardiovascular Publications

We’d like to take a moment to celebrate 10 of our favorite cardiovascular publications from the past couple of years; exploring everything from robotics to stem cells to AI to genomics. Every step made here is a step toward not only better heart health, but a greater understanding of the heart itself.

Collect data from closer to the heart: The Direct Perfusion Core inside our new Rodent Langendorff

How our new compact Langendorff improves data accuracy by allowing measurements to be taken closer to the heart.

Why we redesigned the Langendorff Apparatus

We talk to JC Tan about redesigning the Langendorff Apparatus for improved usability and flexibility.

12 pro tips for Langendorff technique

Essential tips and practical advice from isolated heart expert Dr. Melanie White, for Langendorff heart and perfusion. Covers animal care, heparin, contractility, and more.

Effects of constant flow vs. constant pressure perfusion on isolated heart studies

Check out our brief summary highlighting the advantages and limitations of constant flow vs. constant pressure perfusion setups for Langendorff isolated heart studies.

Langendorff vs. Working Heart Perfusion - What’s the difference?

Here we discuss the differences between Langendorff and Working Heart perfusion models so you can decide which is the best technique for you!

Research highlight: Dissecting the diabetic heart using Langendorff and Proteomics

We talk to cardiovascular researcher, Dr. Melanie White about how she uses Langendorff perfusion and Proteomics to understand the physiology of the diabetic heart.

Watch webinar: An introduction to isolated Langendorff heart - Experimental considerations and best practices

In this free on-demand webinar Dr. Melanie White, Heart Foundation Future Leader Fellow from the University of Sydney, provides a practical and comprehensive introduction to isolated Langendorff heart studies.

Best practices for setting-up an isolated Langendorff heart preparation

Dr. Melanie White, cardiovascular researcher from the University of Sydney, shares her expert advice on best practices and key considerations when performing a Langendorff isolated heart experiment.

Choosing the right perfusate for your isolated Langendorff heart preparation

Dr. Melanie White, cardiovascular researcher at the University of Sydney shares her expert knowledge on choosing the appropriate perfusate system, whether that be crystalloid, whole blood or erythrocyte, when performing an isolated heart experiment.

Three benefits of isolated organ research

What is isolated organ research - and why should you be doing it? Check out three key reasons why isolated organ research may be of benefit in your research lab!

Helping with matters of the (isolated) heart: Simplicity & flexibility for cardiovascular and pharmacology research

Using isolated heart systems? So many variations, so many accessories, too many options! To help, we are pleased to present our updated Isolated Heart Research Kits and Foundation Systems.

High-Quality Laboratory Glassware Products for Life Science Research

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Radnoti

Radnoti's precision-crafted laboratory glassware is designed to meet the stringent requirements of physiological and pharmacological studies. From isolated organ perfusion systems to oxygenating chambers, each glass component is manufactured with durability and accuracy in mind. These high-performance products integrate seamlessly with ADInstruments’ data acquisition systems, enabling researchers to maintain sterile, temperature-controlled, and oxygenated environments for their experiments.